Kim Soo Kyoung, Hur Kyu Yeon, Choi Yoon Ho, Kim Sun Wook, Chung Jae Hoon, Kim Hee Kyung, Lee Moon-Kyu, Min Yong-Ki, Kim Kwang-Won, Kim Jae Hyeon
Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean Diabetes J. 2010 Aug;34(4):253-60. doi: 10.4093/kdj.2010.34.4.253. Epub 2010 Aug 31.
The existence of an association between lung function and metabolic syndrome (MetS) has been debated in cases involving non-obese subjects. To address this debate, we performed a cross-sectional study to investigate the association between lung function and MetS in both obese and non-obese populations.
The present study consisted of a total of 1,951 Korean male subjects. In this study group, we investigated relationships between lung function and MetS risk factors such as fasting serum glucose, systolic blood pressure (SBP), insulin resistance index, waist circumference (WC), and hemoglobin A(1C) level.
Forced vital capacity (FVC) values were significantly lower in the MetS group compared with those of the non-MetS group. In both non-obese (body mass index [BMI] < 25 kg/m(2)) and obese subjects (BMI ≥ 25 kg/m(2)), fasting serum glucose, hemoglobin A(1C) level, insulin resistance index, SBP, WC, and the prevalences of diabetes and MetS were significantly higher in subjects in the lowest FVC quartile compared with those in the highest FVC quartile. Odds ratios for the presence of MetS risk factors, after adjusting for age and height, ranged from 1.21 to 1.39 (P < 0.01) for a one standard deviation decrease in FVC.
The results of our study suggest that decreased vital capacity in Korean adult male subjects is associated with MetS, irrespective of obesity.
在非肥胖受试者中，肺功能与代谢综合征（MetS）之间是否存在关联一直存在争议。为了解决这一争议，我们进行了一项横断面研究，以调查肥胖和非肥胖人群中肺功能与MetS之间的关联。
本研究共纳入1951名韩国男性受试者。在这个研究组中，我们调查了肺功能与MetS危险因素之间的关系，如空腹血糖、收缩压（SBP）、胰岛素抵抗指数、腰围（WC）和糖化血红蛋白A1C水平。
与非MetS组相比，MetS组的用力肺活量（FVC）值显著降低。在非肥胖（体重指数[BMI]<25kg/m²）和肥胖受试者（BMI≥25kg/m²）中，最低FVC四分位数组的空腹血糖、糖化血红蛋白A1C水平、胰岛素抵抗指数、SBP、WC以及糖尿病和MetS的患病率均显著高于最高FVC四分位数组。在调整年龄和身高后，FVC每降低一个标准差，MetS危险因素存在的比值比范围为1.21至1.39（P<0.01）。
我们的研究结果表明，韩国成年男性受试者肺活量降低与MetS相关，与肥胖无关。
