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经口激光显微手术治疗喉癌:激光剂量学概述及原理

Transoral laser microsurgery for laryngeal cancer: a primer and review of laser dosimetry.

机构信息

Department of Otolaryngology - Head and Neck Surgery, University of California Irvine, 101 The City Drive S, Orange, CA 92868, USA.

出版信息

Lasers Med Sci. 2011 Jan;26(1):113-24. doi: 10.1007/s10103-010-0834-5. Epub 2010 Sep 11.

Abstract

Transoral laser microsurgery (TLM) is an emerging technique for the management of laryngeal and other head and neck malignancies. It is increasingly being used in place of traditional open surgery because of lower morbidity and improved organ preservation. Since the surgery is performed from the inside working outward as opposed to working from the outside in, there is less damage to the supporting structures that lie external to the tumor. Coupling the laser to a micromanipulator and a microscope allows precise tissue cutting and hemostasis; thereby improving visualization and precise ablation. The basic approach and principles of performing TLM, the devices currently in use, and the associated dosimetry parameters will be discussed. The benefits of using TLM over conventional surgery, common complications and the different settings used depending on the location of the tumor will also be discussed. Although the CO(2) laser is the most versatile and the best-suited laser for TLM applications, a variety of lasers and different parameters are used in the treatment of laryngeal cancer. Improved instrumentation has lead to an increased utilization of TLM by head and neck cancer surgeons and has resulted in improved outcomes. Laser energy levels and spot size are adjusted to vary the precision of cutting and amount of hemostasis obtained.

摘要

经口激光微创手术(TLM)是一种新兴的治疗喉部和其他头颈部恶性肿瘤的技术。由于其发病率较低,且能更好地保存器官,因此越来越多地取代了传统的开放性手术。由于手术是从内部向外进行的,而不是从外向内进行的,因此对位于肿瘤外部的支撑结构的损伤较小。将激光与微操作器和显微镜相结合,可以实现精确的组织切割和止血,从而提高了可视化和精确消融的效果。本文将讨论 TLM 的基本方法和原理、目前使用的设备以及相关的剂量学参数。还将讨论 TLM 相对于传统手术的优势、常见并发症以及根据肿瘤位置使用的不同设置。虽然 CO2 激光是最通用且最适合 TLM 应用的激光,但在治疗喉癌时也使用了各种激光和不同的参数。改进的仪器设备使头颈部癌症外科医生更多地使用 TLM,并取得了更好的效果。激光能量水平和光斑大小可以进行调整,以改变切割的精度和止血的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091a/2981737/39695f2bdb7a/10103_2010_834_Fig1_HTML.jpg

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