Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct;1(2):247-253. doi: 10.1002/wsbm.13.
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3' OH position of the inositol ring of phosphoinositides on the inner leaf of the plasma membrane. Receptor-mediated activation of the PI3K pathway plays a crucial role in numerous signaling pathways and regulates a number of critical cellular processes, including growth, differentiation, survival and directed migration. In this focus article, we review the temporal and spatial regulation of PI3K in chemotaxing cells with particular emphasis on the amoeba Dictyostelium as well as neutrophils. We also briefly discuss one model used to elucidate the PI3K pathway.
磷酸肌醇 3-激酶（PI3Ks）是一类脂质激酶，可磷酸化质膜内层磷脂酰肌醇的 3' OH 位。受体介导的 PI3K 途径的激活在许多信号通路中发挥关键作用，并调节许多关键的细胞过程，包括生长、分化、存活和定向迁移。在这篇专题文章中，我们回顾了趋化细胞中 PI3K 的时空调节，特别强调了变形虫 Dictyostelium 和中性粒细胞。我们还简要讨论了用于阐明 PI3K 途径的一种模型。
