Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sci Signal. 2011 Apr 26;4(170):pe22. doi: 10.1126/scisignal.2002019.
Although the spatiotemporal activation of phosphoinositide 3-kinases (PI3Ks) at the leading edge of chemotaxing cells represents a key marker of polarity, both Dictyostelium discoideum and neutrophils lacking measurable PI3K activity can still migrate directionally under certain conditions. Evidence from various papers suggests that the differentiation state of cells or their priming status can consolidate otherwise contradictory findings.
尽管磷酸肌醇 3-激酶（PI3Ks）在趋化细胞前缘的时空激活代表了极性的一个关键标志，但在某些条件下，缺乏可测量 PI3K 活性的 Dictyostelium discoideum 和中性粒细胞仍然可以定向迁移。来自不同论文的证据表明，细胞的分化状态或其初始状态可以整合其他相互矛盾的发现。
