Young Daniel E, Wagenaar Robert C, Lin Cheng-Chieh, Chou Ying-Hui, Davidsdottir Sigurros, Saltzman Elliot, Cronin-Golomb Alice
College of Health and Rehabilitation Sciences, Sargent College, Department of Psychology, Boston University, Boston, MA 02215, United States.
Vision Res. 2010 Nov 23;50(23):2495-504. doi: 10.1016/j.visres.2010.08.029. Epub 2010 Sep 15.
A shifted field of view, an altered perception of optic flow speed, and gait asymmetries may influence heading direction in Parkinson's disease (PD). PD participants (left body-side onset, LPD, n=14; right body-side onset, RPD, n=9) and Healthy Control participants (n=17) walked a virtual hallway in which the optic flow speeds of the walls varied. Three-dimensional kinematics showed participants veered away from the faster moving wall. Although veering normally occurs toward the side with smaller step length, in both LPD and RPD this bias was overridden by a shifted field of view, which caused veering in the opposite direction, toward the side of the brain with more basal ganglia damage.
视场偏移、对视流速度的感知改变以及步态不对称可能会影响帕金森病（PD）患者的行进方向。帕金森病患者（左侧身体起病，LPD，n = 14；右侧身体起病，RPD，n = 9）和健康对照者（n = 17）在一个虚拟走廊中行走，走廊墙壁的视流速度各不相同。三维运动学显示，参与者会偏离移动速度较快的墙壁。尽管通常会朝着步长较小的一侧转向，但在LPD和RPD患者中，这种偏向被视场偏移所抵消，视场偏移导致朝着基底神经节损伤更严重的大脑一侧转向，方向相反。
