Department of Cariology, Institute of Odontology at the Sahlgrenska Academy, University of Gothenburg, Public Dental Health Service of Västra Götaland, Gothenburg, Sweden.
Caries Res. 2010;44(5):453-8. doi: 10.1159/000320168. Epub 2010 Sep 13.
The efficacy of early maternal caries prevention in children was evaluated.
First-time mothers selected on the basis of a high level of salivary mutans streptococci (MS) and mothers excluded at screening due to a low level of MS ('low') were recalled when their children were 11 years old. The salivary MS level was determined in the mothers. Their children were examined for salivary MS and lesion prevalence (decayed and filled surfaces, DFS) at the ages of 11 and 15 years.
More 'high control' mothers displayed ≥10⁶ MS than the 'high interventional' and 'low control' mothers and, vice versa, more 'interventional' and 'low control' mothers had MS counts of <3 × 10⁵ than 'high control' mothers. More of 'interventional' and 'low control' children had <10⁵ MS/ml as compared with the 'high control' children. All the 'high control' children had detectable MS. MS were undetected in 5 'interventional' and 5 'low control' children at 15 years. Significantly fewer 'high control' than 'interventional' and 'low control' children were caries free at 11 and 15 years of age. Non-MS-colonised children at 3 years of age, irrespective of group identity, displayed statistically lower MS counts and less DFS at 15 years than those colonised at 3 years of age. Children with clinical caries/fillings at 15 years had had a significantly higher level of MS at 11 years of age than those without clinical caries/fillings.
The clinical trial, focusing on the mothers, resulted in long-term benefits for their children. Children colonised by MS at an early stage developed more caries than those colonised at a later stage.
评估儿童早期龋病预防的效果。
选择唾液变形链球菌水平较高的初产妇（高组），并在筛查时排除因变形链球菌水平较低（低组）的产妇。当她们的孩子 11 岁时，召回这些母亲。在母亲中测定唾液变形链球菌水平。在孩子 11 岁和 15 岁时，检查他们的唾液变形链球菌水平和病变流行率（龋失补牙面数，DFS）。
更多的“高对照组”母亲显示的变形链球菌计数≥10⁶，而“高干预组”和“低对照组”母亲的计数则相反，更多的“干预组”和“低对照组”母亲的变形链球菌计数<3×10⁵，而“高对照组”母亲的计数则相反。更多的“干预组”和“低对照组”孩子的变形链球菌计数<10⁵/ml，而“高对照组”孩子的计数则相反。所有“高对照组”孩子都能检测到变形链球菌。在 15 岁时，有 5 名“干预组”和 5 名“低对照组”孩子没有检测到变形链球菌。与“干预组”和“低对照组”相比，“高对照组”的孩子在 11 岁和 15 岁时无龋的比例显著更低。3 岁时非变形链球菌定植的孩子，无论组别的身份如何，在 15 岁时的变形链球菌计数和 DFS 均显著低于 3 岁时已定植的孩子。15 岁时有临床龋/充填的孩子，11 岁时的变形链球菌水平明显高于无临床龋/充填的孩子。
这项以母亲为重点的临床试验，为她们的孩子带来了长期的益处。在早期阶段就被变形链球菌定植的孩子比在后期阶段被定植的孩子更容易患龋病。
