Department of Cariology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Caries Res. 2012;46(5):474-80. doi: 10.1159/000339665. Epub 2012 Jul 13.
The efficacy of early maternal caries prevention was evaluated. Furthermore, the difference between children colonised with mutans streptococci (MS) at an early or late stage with regard to the prevalence of carious lesions was determined.
The children of first-time mothers selected on the basis of high salivary levels of MS for participation in a caries prevention programme were recalled at the age of 19 years. They were examined for salivary MS, lesion prevalence (decayed and filled surfaces, DFS) and MS in plaque from 12 selected proximal surfaces.
The recall rate was 70% for the children of both the high-control and interventional groups. All high-control children and 67% of the interventional children were colonised by MS. All the children with non-detectable MS in saliva were also negative in all plaque samples. No statistically significant difference was found between the groups in terms of DFS, although more interventional children were caries free than in the control group. Early-colonised children, irrespective of group identity, had higher salivary MS levels and DFS than later MS-colonised children.
The results indicate that it is possible to remain negative for MS into adulthood if non-colonised at an early age and this affects the development of carious lesions. Strategies for the prevention of dental caries in early childhood should, therefore, include measures to prevent or delay early colonisation by cariogenic bacteria.
评估早期母体龋齿预防的效果。此外，还确定了在早期或晚期阶段被变形链球菌（MS）定植的儿童与龋齿病变的流行率之间的差异。
根据 MS 唾液水平高的初产妇选择参与龋齿预防计划的儿童，在 19 岁时召回。检查唾液 MS、病变流行率（龋齿和补牙表面，DFS）和 12 个选定的近表面菌斑中的 MS。
高对照组和干预组的儿童召回率均为 70%。所有高对照组的儿童和 67%的干预组儿童均被 MS 定植。所有唾液中 MS 不可检测的儿童在所有菌斑样本中均为阴性。尽管干预组中无龋齿的儿童比例高于对照组，但两组之间在 DFS 方面没有统计学上的显著差异。无论组间身份如何，早期定植的儿童的唾液 MS 水平和 DFS 均高于晚期定植的儿童。
结果表明，如果儿童在早期未被 MS 定植，则有可能在成年后保持 MS 阴性，这会影响龋齿病变的发展。因此，幼儿期龋齿预防策略应包括预防或延迟致龋菌早期定植的措施。
