妊娠合并双侧乳腺受累的伯基特淋巴瘤：病例报告并文献复习

Burkitt's lymphoma in pregnancy with bilateral breast involvement: case report with review of the literature.

作者信息

Savvari Paraskevi, Matsouka Chara, Barbaroussi Despoina, Christoulas Dimitrios, Nikitas Nikitas, Dimopoulos Meletios-A, Papadimitriou Christos A

机构信息

Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece.

出版信息

Onkologie. 2010;33(8-9):461-4. doi: 10.1159/000317344. Epub 2010 Jul 26.

DOI:10.1159/000317344

PMID:20838063

Abstract

BACKGROUND

Burkitt's lymphoma (BL) in pregnancy presenting with breast involvement is a rare clinical entity, and only 13 cases have been reported so far.

CASE REPORT

We describe the case of a 28-year-old postpartum woman who presented with markedly enlarged breasts caused by BL. She was treated with 8 cycles of the CALGB 10002 regimen, as well as with irradiation to both breasts. After achieving a complete objective response, the patient received consolidation with high dose BEAM followed by autologous stem cell transplantation. 20 months after the initial diagnosis, our patient remains alive and relapse-free. Data extracted from the published case reports include information regarding demographic details, type of treatment, sites of disease, and survival. The clinical outcome of the reviewed cases was very unfavorable.

CONCLUSIONS

BL affecting breasts during pregnancy or lactation is a rare entity that requires a prompt diagnosis and an aggressive therapeutic approach.

摘要

背景

孕期出现乳腺受累的伯基特淋巴瘤（BL）是一种罕见的临床病症，迄今为止仅报告了13例。

病例报告

我们描述了一名28岁产后女性的病例，她因伯基特淋巴瘤导致乳房明显肿大。她接受了8个周期的CALGB 10002方案治疗，以及双侧乳房放疗。在达到完全客观缓解后，患者接受了大剂量BEAM巩固治疗，随后进行自体干细胞移植。初始诊断20个月后，我们的患者仍然存活且未复发。从已发表的病例报告中提取的数据包括人口统计学细节、治疗类型、疾病部位和生存情况等信息。所审查病例的临床结果非常不理想。