颗粒状和可溶性铬酸盐对抹香鲸（Physeter macrocephalus）皮肤成纤维细胞的遗传毒性。
The genotoxicity of particulate and soluble chromate in sperm whale (physeter macrocephalus) skin fibroblasts.
机构信息
Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, Maine, USA.
出版信息
Environ Mol Mutagen. 2011 Jan;52(1):43-9. doi: 10.1002/em.20579.
Abstract
Hexavalent chromium is a marine pollutant of concern, both for the health of ocean ecosystems and for public health. Hexavalent chromium is known to induce genotoxicity in human and other terrestrial mammals. It is also known to be present in both water and air in the marine environment. However, currently there are limited data concerning both chromium levels and its toxicological effects in marine mammals. This study investigated the cytotoxic and genotoxic effects of soluble and particulate hexavalent chromium in sperm whale skin fibroblasts. Both forms of hexavalent chromium induced concentration-dependent increases in cytotoxicity and genotoxicity indicating that these compounds can be a health risk if the whales are exposed to them. These data support a hypothesis that chromium is a concern in the marine environment in general and for the health of sperm whales in particular.
摘要
六价铬是一种海洋污染物，不仅对海洋生态系统的健康，也对公众健康构成威胁。六价铬已知会在人类和其他陆地哺乳动物中引起遗传毒性。它也存在于海洋环境中的水和空气中。然而，目前关于海洋哺乳动物中铬的水平及其毒理学效应的数据有限。本研究调查了可溶性和颗粒状六价铬对抹香鲸皮肤成纤维细胞的细胞毒性和遗传毒性影响。两种形式的六价铬都诱导了浓度依赖性的细胞毒性和遗传毒性增加，表明如果鲸鱼暴露于这些化合物，它们可能会对健康构成风险。这些数据支持了一种假设，即铬是海洋环境中普遍存在的问题，特别是对抹香鲸的健康构成威胁。
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