Department of Obstetrics and Gynecology, University of Thessalia Medical School, Larissa, Greece.
Ann N Y Acad Sci. 2010 Sep;1205:5-11. doi: 10.1111/j.1749-6632.2010.05660.x.
Folliculogenesis in humans is a lengthy process that involves several regulators. Pituitary gonadotropins play crucial roles in the late stages, particularly in the last 15 days of follicle maturation. During the intercycle rise of follicle-stimulating hormone (FSH), selection of the dominant follicle takes place. This is a complex process that also involves locally produced substances. At the same time, luteinizing hormone (LH) stimulates the synthesis of androgens, which serve as the substrate for the production of estrogens. During the second half of the follicular phase, the follicle becomes dependent on LH. Induction of multiple follicular development by exogenous FSH results in a marked suppression of endogenous LH. For normal follicle maturation, both an LH threshold and an LH ceiling have been considered. In the context of an in vitro fertilization program, application of protocols for ovarian stimulation that will prevent the marked suppression of endogenous LH secretion might provide a better approach to treatment optimization.
人类的卵泡发生是一个漫长的过程，涉及到几个调节因子。垂体促性腺激素在晚期，特别是在卵泡成熟的最后 15 天中起着关键作用。在卵泡刺激素 (FSH) 的周期性上升期间，优势卵泡的选择发生。这是一个复杂的过程，也涉及到局部产生的物质。同时，黄体生成素 (LH) 刺激雄激素的合成，雄激素作为雌激素产生的底物。在卵泡期的后半段，卵泡对 LH 产生依赖性。外源性 FSH 诱导多个卵泡发育会导致内源性 LH 的明显抑制。对于正常的卵泡成熟，已经考虑了 LH 阈值和 LH 上限。在体外受精计划的背景下，应用不会显著抑制内源性 LH 分泌的卵巢刺激方案可能为治疗优化提供更好的方法。
