Department of Occupational and Environmental Medicine, Imperial College (NHLI), 18 Manresa Road, London, UK.
Clin Exp Allergy. 2010 Nov;40(11):1593-601. doi: 10.1111/j.1365-2222.2010.03609.x. Epub 2010 Sep 14.
Allergy to rodents in the workplace is an important occupational health problem affecting research, pharmaceutical and toxicological sectors and can have a serious impact on employees working in this area. Despite measures to reduce aeroallergen exposures to rodents in the workplace, there are few signs that this occupational health problem is declining. Rodent allergens are well characterized and exposure-response relationships have been demonstrated to be complex. More recently, the importance of rodent allergens outside of the workplace has been demonstrated in several studies of individuals with asthma. This review focuses on rodent allergy both in the workplace and in the home and examines the complex exposure-response relationships between allergen exposure and sensitization and asthma. Risk factors for rodent allergy and mechanisms of tolerance to rodent allergens are discussed.
工作场所中对啮齿动物过敏是一个重要的职业健康问题，影响着研究、制药和毒理学领域，并且可能对在这个领域工作的员工产生严重影响。尽管已经采取措施减少工作场所中啮齿动物的过敏原暴露，但几乎没有迹象表明这个职业健康问题正在减少。啮齿动物过敏原的特征已经得到很好的描述，并且已经证明了暴露-反应关系是复杂的。最近，在几项对哮喘患者的研究中，已经证明了工作场所之外的啮齿动物过敏原的重要性。这篇综述重点讨论了工作场所和家庭中的啮齿动物过敏，并研究了过敏原暴露与致敏以及哮喘之间复杂的暴露-反应关系。还讨论了啮齿动物过敏的危险因素和对啮齿动物过敏原的耐受机制。
