Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/IdiPAZ-Biomedical Research Centre Network for Epidemiology and Public Health, Madrid, Spain.
J Am Geriatr Soc. 2010 Oct;58(10):1870-7. doi: 10.1111/j.1532-5415.2010.03071.x. Epub 2010 Sep 14.
To examine the association between usual sleep duration and mortality according to physical and mental health status in older adults.
Prospective study conducted from 2001 to 2008.
Community-based study.
Cohort study of 3,820 persons representative of the noninstitutionalized population aged 60 and older in Spain.
Sleep duration was self-reported at baseline. Analyses were performed using Cox regression and adjusted for the main confounders. The analyses were then stratified according to numerous indicators of health status.
During follow-up, 897 persons died. Mortality was higher in those who slept 8 hours (relative risk (RR)=1.34, 95% confidence interval (CI)=1.02-1.76), 9 hours (RR 1.48, 95% CI=1.12-1.96), 10 hours (RR 1.73, 95% CI=1.30-2.29) and 11 hours or more (RR 1.66, 95% CI=1.23-2.24) than in those who slept 7 hours (P for trend <.001). The association between long sleep duration (≥10 vs 7 hours) and mortality was observed even in persons with good health status: optimal perceived health, good cognitive function (Mini-Mental State Examination score >27), no depression, quality of life better than the cohort median (Medical Outcomes Study 36-item Short Form Survey Physical Component Summary score ≥46 and Mental Component Summary score ≥52), and without disability in instrumental activities of daily living. Sleeping 6 hours or less was not associated with higher mortality than sleeping 7 hours in persons with good health status.
Self-reported sleep duration was associated with 7-year mortality in this cohort of older adults, even when adjusted for health status. Further research is needed to determine the mechanisms and clinical implications of these findings.
探讨老年人的通常睡眠时间与身心健康状况与死亡率之间的关系。
2001 年至 2008 年进行的前瞻性研究。
基于社区的研究。
代表西班牙 60 岁及以上非住院人群的 3820 名队列研究对象。
在基线时自我报告睡眠持续时间。使用 Cox 回归分析，并根据主要混杂因素进行调整。然后根据许多健康状况指标对分析进行分层。
在随访期间，有 897 人死亡。睡眠时间为 8 小时（相对风险 (RR)=1.34，95%置信区间 (CI)=1.02-1.76）、9 小时（RR 1.48，95% CI=1.12-1.96）、10 小时（RR 1.73，95% CI=1.30-2.29）和 11 小时或更长时间（RR 1.66，95% CI=1.23-2.24）的人死亡率高于睡眠时间为 7 小时的人（趋势 P<.001）。即使在健康状况良好的人群中，长睡眠时间（≥10 小时与 7 小时）与死亡率之间也存在关联：最佳感知健康、良好的认知功能（Mini-Mental State Examination 评分>27）、无抑郁、生活质量优于队列中位数（Medical Outcomes Study 36-item Short Form Survey 身体成分综合评分≥46 和心理成分综合评分≥52）、以及日常生活活动的工具性活动无残疾。在健康状况良好的人群中，睡眠时间为 6 小时或更短与死亡率升高无关。
在这项老年队列研究中，自我报告的睡眠时间与 7 年死亡率相关，即使在调整了健康状况后也是如此。需要进一步研究以确定这些发现的机制和临床意义。
