Beth Israel Deaconess Medical Center, 110 Francis St, Boston, MA 02215, USA.
J Vasc Surg. 2010 Dec;52(6):1471-7. doi: 10.1016/j.jvs.2010.07.013. Epub 2010 Sep 16.
Obesity and morbid obesity have been shown to increase wound infections and occasionally mortality after many surgical procedures. Little is known about the relative impact of body mass index (BMI) on these outcomes after open (OAR) and endovascular abdominal aortic aneurysm repair (EVAR).
The 2005-2007 National Surgical Quality Improvement Program (NSQIP), a multi-institutional risk-adjusted database, was retrospectively queried to compare perioperative mortality (in-hospital or 30-day) and postoperative wound infections after OAR and EVAR. Patient demographics, comorbidities, and operative details were analyzed. Obesity was defined as a BMI >30 kg/m(2) and morbid obesity as a BMI >40 kg/m(2). Outcomes were compared with t test, Wilcoxon rank sum, χ(2), and multivariate logistic regression.
There were 2097 OARs and 3358 EVARs. Compared with EVAR, OAR patients were younger, more likely to be women (26% vs 17%, P < .001), and less obese (27% vs 32%, P < .001). Mortality was 3.7% after OAR vs 1.2% after EVAR (risk ratio, 3.1; P < .001), and overall morbidity was 28% vs 12%, respectively (relative risk, 2.3; P < .001). Morbidly obese patients had a higher mortality for both OAR (7.3%) and EVAR (2.4%) than obese patients (3.9% OAR; 1.5% EVAR) or nonobese patients (3.7% OAR; 1.1% EVAR). Obese patients had a higher rate of wound infection vs nonobese after OAR (6.3% vs 2.4%, P < .001) and EVAR (3.3% vs 1.5%, P < .001). Morbid obesity predicted death after OAR but not after EVAR, and obesity was an independent predictor of wound infection after OAR and EVAR.
Morbid obesity confers a worse outcome for death after abdominal aortic aneurysm repair. Obesity is also a risk factor for infectious complications after OAR and EVAR. Obese patients and, particularly, morbidly obese patients should be treated with EVAR when anatomically feasible.
肥胖和病态肥胖已被证明会增加许多手术后的伤口感染,偶尔还会导致死亡。关于身体质量指数(BMI)对开放式(OAR)和血管内腹主动脉瘤修复(EVAR)后这些结果的相对影响,知之甚少。
回顾性查询 2005-2007 年国家手术质量改进计划(NSQIP),这是一个多机构风险调整数据库,以比较 OAR 和 EVAR 后的围手术期死亡率(住院或 30 天内)和术后伤口感染。分析患者的人口统计学、合并症和手术细节。肥胖定义为 BMI>30kg/m(2),病态肥胖定义为 BMI>40kg/m(2)。使用 t 检验、Wilcoxon 秩和检验、χ(2)检验和多变量逻辑回归比较结果。
OAR 有 2097 例,EVAR 有 3358 例。与 EVAR 相比,OAR 患者更年轻,女性比例更高(26%比 17%,P<0.001),肥胖程度较低(27%比 32%,P<0.001)。OAR 的死亡率为 3.7%,EVAR 的死亡率为 1.2%(风险比,3.1;P<0.001),总体发病率分别为 28%和 12%(相对风险,2.3;P<0.001)。OAR 和 EVAR 中病态肥胖患者的死亡率均高于肥胖患者(7.3%和 2.4%)和非肥胖患者(3.9%和 1.1%)。肥胖患者的 OAR 术后伤口感染发生率高于非肥胖患者(6.3%比 2.4%,P<0.001)和 EVAR(3.3%比 1.5%,P<0.001)。病态肥胖预测 OAR 后死亡,但不预测 EVAR 后死亡,肥胖是 OAR 和 EVAR 后感染并发症的独立预测因素。
病态肥胖会增加腹主动脉瘤修复后死亡的风险。肥胖也是 OAR 和 EVAR 后感染并发症的危险因素。当解剖结构可行时,肥胖患者,特别是病态肥胖患者应接受 EVAR 治疗。