大鼠胃旁路手术后甜味觉减退。
Decrease in sweet taste in rats after gastric bypass surgery.
机构信息
Department of Surgery, Thomas Jefferson University, 1100 Walnut Street, 5th Floor, Philadelphia, PA 19107, USA.
出版信息
Surg Endosc. 2011 Apr;25(4):1176-81. doi: 10.1007/s00464-010-1335-0. Epub 2010 Sep 16.
BACKGROUND
The literature contains evidence that Roux-en-Y gastric bypass (RYGB) surgery has an effect in humans on taste and preference for carbohydrate-rich foods. This study tested the hypothesis that RYGB affects sweet taste behavior using a rat model.
METHODS
Male Sprague-Dawley rats underwent either RYGB or sham surgery. Then 4 weeks after surgery, the rats were given taste-salient, brief-access lick tests with a series of sucrose concentrations.
RESULTS
The RYGB rats, but not the sham rats, lost weight over the 5-week postoperative period. The RYGB rats showed a significant decrease in mean licks for the highest concentration of sucrose (0.25-1.0 mol/l) but not for the low concentrations of sucrose or water.
CONCLUSIONS
The findings showed that RYGB surgery affected sweet taste behavior in rats, with postsurgical rats having lower sensitivity or avidity for sucrose than sham-treated control rats. This finding is similar to human reports that sweet taste and preferences for high-caloric foods are altered after bypass surgery.
背景
文献中有证据表明，Roux-en-Y 胃旁路（RYGB）手术会对人类对富含碳水化合物的食物的味觉和偏好产生影响。本研究使用大鼠模型检验了 RYGB 影响甜味味觉行为的假设。
方法
雄性 Sprague-Dawley 大鼠接受 RYGB 或假手术。手术后 4 周，大鼠接受味觉显著、短暂接触的舔食测试，使用一系列蔗糖浓度。
结果
RYGB 组大鼠在术后 5 周期间体重减轻，而假手术组大鼠体重没有减轻。RYGB 组大鼠对最高浓度蔗糖（0.25-1.0 mol/L）的平均舔食次数显著减少，但对低浓度蔗糖或水的舔食次数没有减少。
结论
研究结果表明，RYGB 手术会影响大鼠的甜味味觉行为，术后大鼠对蔗糖的敏感性或嗜食性低于假手术对照组大鼠。这一发现与人类报告的手术后甜味和高热量食物偏好改变相似。
Zotero 插件