Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Nutrients. 2022 Feb 18;14(4):866. doi: 10.3390/nu14040866.
Obesity surgery is a highly efficacious treatment for obesity and its comorbidities. The underlying mechanisms of weight loss after obesity surgery are not yet fully understood. Changes to taste function could be a contributing factor. However, the pattern of change in different taste domains and among obesity surgery operations is not consistent in the literature. A systematic search was performed to identify all articles investigating gustation in human studies following bariatric procedures. A total of 3323 articles were identified after database searches, searching references and deduplication, and 17 articles were included. These articles provided evidence of changes in the sensory and reward domains of taste following obesity procedures. No study investigated the effect of obesity surgery on the physiological domain of taste. Taste detection sensitivity for sweetness increases shortly after Roux-en-Y gastric bypass. Additionally, patients have a reduced appetitive reward value to sweet stimuli. For the subgroup of patients who experience changes in their food preferences after Roux-en-Y gastric bypass or vertical sleeve gastrectomy, changes in taste function may be underlying mechanisms for changing food preferences which may lead to weight loss and its maintenance. However, data are heterogeneous; the potential effect dilutes over time and varies significantly between different procedures.
肥胖症手术是治疗肥胖及其合并症的一种高效疗法。然而，肥胖症手术减轻体重的潜在机制尚未完全被理解。味觉功能的改变可能是一个促成因素。然而，在文献中，不同肥胖症手术操作后的不同味觉领域的变化模式并不一致。进行了一项系统性检索，以确定所有调查人类肥胖症手术后味觉的研究文章。在数据库搜索、参考文献搜索和重复项剔除后，共确定了 3323 篇文章，其中包括 17 篇文章。这些文章提供了肥胖症手术后味觉的感觉和奖励领域发生变化的证据。没有研究调查肥胖症手术对味觉的生理领域的影响。Roux-en-Y 胃旁路手术后，甜味的检测敏感性会短暂增加。此外，患者对甜味刺激的食欲奖励价值降低。对于在 Roux-en-Y 胃旁路或垂直袖状胃切除术后经历食物偏好改变的患者亚组，味觉功能的改变可能是改变食物偏好的潜在机制，这可能导致体重减轻及其维持。然而，数据存在异质性；潜在的影响随着时间的推移而稀释，并且在不同的手术之间存在显著差异。
