Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Sleep Breath. 2011 Sep;15(3):599-606. doi: 10.1007/s11325-010-0409-5. Epub 2010 Sep 16.
Continuous positive airway pressure (CPAP) improves depressive symptoms and daytime sleepiness in patients with obstructive sleep apnea (OSA). However, there is variability in response to CPAP. This study examined individual differences in the daily associations between CPAP use and improvements in affect and sleepiness patients beginning CPAP.
This observational repeated measures study involved 31 CPAP-naïve patients diagnosed with obstructive sleep apnea at an academic sleep disorders center. Patients completed pre-treatment assessments of OSA knowledge, expectations for CPAP, and treatment self-efficacy as well as a repeated daily assessment of positive affect and negative affect, sleepiness/fatigue, and CPAP adherence for 10 days beginning the first week of treatment. Data were analyzed using multilevel modeling.
Nightly CPAP adherence predicted improvements in next-day positive affect, negative affect, and sleepiness/fatigue. The apnea-hypopnea index (AHI), treatment self-efficacy, and outcome expectancies were significant moderators of day-to-day improvement. Higher self-efficacy and lower AHI were associated with a stronger relationship between adherence and next-day improvements in positive affect and sleepiness. Very high-outcome expectances were associated with a weaker relationship between adherence and next-day improvements in sleepiness. Subjective sleepiness at pre-treatment did not give moderate improvements in next-day affect.
Although CPAP use predicted daily improvements in affect and sleepiness for the majority of patients, patients with lower AHI, greater treatment self-efficacy, and moderate outcome expectancies reported stronger daily benefits from CPAP. For patients with high-treatment efficacy, adherence may be reinforced by a stronger link between adherence and daily improvements.
持续气道正压通气(CPAP)可改善阻塞性睡眠呼吸暂停(OSA)患者的抑郁症状和日间嗜睡。然而,CPAP 的反应存在差异。本研究考察了 CPAP 治疗开始时患者 CPAP 使用与情绪和嗜睡改善之间的日常关联的个体差异。
本观察性重复测量研究纳入了 31 名在学术睡眠障碍中心诊断为阻塞性睡眠呼吸暂停的 CPAP 初治患者。患者在治疗前完成了 OSA 知识、CPAP 预期、治疗自我效能的评估,以及在治疗开始后的第一周内连续 10 天对积极情绪和消极情绪、嗜睡/疲劳以及 CPAP 依从性进行每日重复评估。使用多层线性模型对数据进行分析。
夜间 CPAP 依从性预测次日积极情绪、消极情绪和嗜睡/疲劳的改善。呼吸暂停低通气指数(AHI)、治疗自我效能和结果预期是日间改善的显著调节因素。更高的自我效能和更低的 AHI 与依从性与次日积极情绪和嗜睡改善之间的关系更强相关。非常高的结果预期与依从性与次日嗜睡改善之间的关系较弱相关。治疗前的主观嗜睡并不能改善次日的情绪。
尽管 CPAP 使用预测了大多数患者情绪和嗜睡的日常改善,但 AHI 较低、治疗自我效能较高和结果预期适中的患者报告 CPAP 具有更强的日常获益。对于治疗效果较高的患者,依从性与日常改善之间的联系可能更强,从而增强了依从性。