Wang Gang, Wang Guo-Kai, Liu Jin-Song, Yu Bo, Wang Fei, Liu Ji-Kai
School of Materia Madica, Anhui University of Traditional Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material Medical, Hefei 230031, China.
Zhong Yao Cai. 2010 Apr;33(4):551-4.
To study the chemical constituents from Kalimeris indica.
Compounds were isolated and purified with silica gel and Sephadex LH-20 column chromatography, their structures were determined by using spectroscopic analysis including MS and NMR.
Nine compounds were isolated and identified as tritriacontane (I), hexadecanol (II), chrysophanol (III), vanillin (IV), physcion (V), beta-sitosterol (VI), stigmasterol (VII), leinoleic acid (VII), emodin (IX).
All of them, except compound IV, VI, are isolated from this genus for the first time. Compound III, IV had the protective effects with the toxicity of CCl4 on primary cultered hepatocytes.
研究马兰的化学成分。
采用硅胶柱色谱和葡聚糖凝胶LH-20柱色谱分离纯化化合物，通过质谱（MS）和核磁共振（NMR）等光谱分析确定其结构。
分离鉴定出9种化合物，分别为三十烷（I）、十六醇（II）、大黄酚（III）、香草醛（IV）、大黄素甲醚（V）、β-谷甾醇（VI）、豆甾醇（VII）、亚油酸（VIII）、大黄素（IX）。
除化合物IV、VI外，其余化合物均为首次从该属植物中分离得到。化合物III、IV对四氯化碳损伤原代培养肝细胞具有保护作用。
