Melichar Bohuslav, Morávek Petr, Ferko Alexander, Podhola Miroslav
Department of Oncology Palacký University Medical School Teaching Hospital, Olomouc, Czech Republic.
Tumori. 2010 May-Jun;96(3):483-6. doi: 10.1177/030089161009600318.
The prognosis of patients with metastatic colorectal carcinoma (CRC) has improved substantially over the last two decades. Longer patient survival comes at a price of more complications, including second primary neoplasms and metastases at unusual sites.
Retrospective chart review.
We present 4 patients with metastatic CRC who developed kidney tumors. In 2 cases, partial nephrectomy or nephrectomy was performed for second primary renal cell carcinoma. The patients survived 2.5 and more than 6 years after kidney surgery. In the other 2 patients the kidney tumors were diagnosed as CRC metastases, histologically verified in one case; these two patients died within two years of diagnosis of kidney involvement.
The diagnostic approach to kidney tumors in CRC patients should include a biopsy because only patients with primary renal cell carcinoma and selected patients with metastatic CRC benefit from nephrectomy.
在过去二十年中，转移性结直肠癌（CRC）患者的预后有了显著改善。患者生存期延长的代价是出现更多并发症，包括第二原发性肿瘤和不常见部位的转移。
回顾性病历审查。
我们报告了4例发生肾肿瘤的转移性CRC患者。2例因第二原发性肾细胞癌行部分肾切除术或肾切除术。这两名患者在肾脏手术后分别存活了2.5年和6年以上。另外2例患者的肾肿瘤被诊断为CRC转移，其中1例经组织学证实；这两名患者在诊断肾脏受累后的两年内死亡。
CRC患者肾肿瘤的诊断方法应包括活检，因为只有原发性肾细胞癌患者和部分转移性CRC患者能从肾切除术中获益。
