Anal Chem. 2010 Oct 15;82(20):8382-5. doi: 10.1021/ac101951j.
This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.
这封信介绍了首次使用表面增强拉曼光谱(SERS)进行的定量、活体经皮葡萄糖测量。银膜覆盖纳米球(AgFON)表面通过混合自组装单分子层(SAM)进行功能化,并植入 Sprague-Dawley 大鼠的皮下。在间质液中监测葡萄糖浓度。通过使用空间偏移拉曼光谱(SORS)从皮肤透过传感器芯片收集 SER 光谱。SERS 和 SORS 的结合为解决活体代谢物和药物传感这一具有挑战性的问题提供了一种强大的新方法。