Faculty of Life Sciences, University of Manchester, Manchester, UK.
FEMS Yeast Res. 2010 Dec;10(8):1083-9. doi: 10.1111/j.1567-1364.2010.00676.x.
The common baker's yeast, Saccharomyces cerevisiae, is one of the oldest domesticated organisms known, and has been exploited by our ancestors in several different applications, particularly in food and fermentations industries and in bioconversion and biodegradation processes. Over the years, yeast has become an excellent experimental model for biological and medical studies, thanks to its genetic tractability, well-known physiology and fast-doubling cycle. In the last decade, the advances in genome sequencing opened the doors to high-throughput studies and yeast quickly has become a model system for drug discovery and mode of action. This review provides a focused overview of the achievements in the field of human medicine and pharmacology by exploiting the molecular tools available for yeast.
常见的面包酵母，即酿酒酵母，是已知最古老的驯化生物之一，我们的祖先曾在多个不同的领域中利用酵母，尤其是在食品和发酵工业，以及生物转化和生物降解过程中。多年来，由于其遗传稳定性、众所周知的生理学特性和快速的倍增周期，酵母已成为生物学和医学研究的优秀实验模型。在过去的十年中，基因组测序的进步为高通量研究开辟了道路，酵母也迅速成为药物发现和作用模式的模型系统。本综述通过利用现有的酵母分子工具，重点介绍了在人类医学和药理学领域所取得的成就。
