从药物到蛋白质：利用酵母遗传学进行高通量靶点发现

From drug to protein: using yeast genetics for high-throughput target discovery.

作者信息

Armour Christopher D, Lum Pek Yee

机构信息

Rosetta Inpharmatics LLC, Merck & Co., Inc., 401 Terry Avenue North, Seattle, Washington 98109, USA.

出版信息

Curr Opin Chem Biol. 2005 Feb;9(1):20-4. doi: 10.1016/j.cbpa.2004.12.001.

DOI:10.1016/j.cbpa.2004.12.001

PMID:15701448

Abstract

The budding yeast Saccharomyces cerevisiae has long been an effective eukaryotic model system for understanding basic cellular processes. The genetic tractability and ease of manipulation in the laboratory make yeast well suited for large-scale chemical and genetic screens. Several recent studies describing the use of yeast genetics for high-throughput drug target identification are discussed in this review.

摘要

出芽酵母酿酒酵母长期以来一直是用于理解基本细胞过程的有效真核模式系统。其遗传易处理性以及在实验室中易于操作的特点使酵母非常适合大规模化学和遗传筛选。本综述讨论了最近几项描述利用酵母遗传学进行高通量药物靶点鉴定的研究。