非酒精性脂肪性肝病的严重程度与高敏 C 反应蛋白值相关，且与健康人群心血管风险增加独立相关。
The severity of non-alcoholic fatty liver disease correlates with high sensitivity C-reactive protein value and is independently associated with increased cardiovascular risk in healthy population.
机构信息
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
出版信息
Clin Biochem. 2010 Dec;43(18):1399-404. doi: 10.1016/j.clinbiochem.2010.09.003. Epub 2010 Sep 19.
OBJECTIVES
We aimed to investigate the correlation between non-alcoholic fatty liver disease (NAFLD) and risk of cardiovascular disease (CVD).
DESIGN AND METHODS
We analyzed 724 subjects without CVD according to presence or absence of NAFLD. Logistic regression model was used to determine if NAFLD was an independent risk factor of CVD.
RESULTS
Subjects with NAFLD had increased percentage of 10-year cardiovascular risk ≧10% compared to those without NAFLD (p<0.001). The severity of NAFLD significantly correlated with increasing Framingham risk score and C-relative protein (CRP) value. After adjusting for conventional CVD risk factors, the presence of NAFLD was an independent predictor for future CVD risk ≧10% [odds ratio: 1.89, p=0.004]. Subgroup analysis showed the predictive value of NAFLD was significant among aged subjects and those with increased baseline hsCRP level.
CONCLUSIONS
NAFLD is independently associated with increased CVD risk, especially among elderly subjects and those with increased CRP level.
目的
我们旨在研究非酒精性脂肪性肝病（NAFLD）与心血管疾病（CVD）风险之间的相关性。
设计和方法
我们根据是否存在 NAFLD 分析了 724 例无 CVD 的受试者。使用逻辑回归模型确定 NAFLD 是否是 CVD 的独立危险因素。
结果
与无 NAFLD 者相比，存在 NAFLD 的受试者 10 年心血管风险 ≧10%的比例增加（p<0.001）。NAFLD 的严重程度与Framingham 风险评分和 C-反应蛋白（CRP）值的增加显著相关。在校正了传统的 CVD 危险因素后，存在 NAFLD 是未来 CVD 风险 ≧10%的独立预测因子[比值比：1.89，p=0.004]。亚组分析显示，NAFLD 在老年受试者和基线 hsCRP 水平升高的患者中具有显著的预测价值。
结论
NAFLD 与 CVD 风险增加独立相关，尤其是在老年患者和 CRP 水平升高的患者中。
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