非酒精性脂肪性肝病患者高敏C反应蛋白与肝脏弹性成像及心脏缺血性疾病的相关性
Association between high-sensitivity-CRP and liver elastography and cardiac ischemic diseases in patients with fatty liver.
作者信息
Nayebi Morteza, Seyedian Seyed Saeed, Hashemi Seyed Jalal, Parsi Abazar, Hajiani Eskandar
机构信息
Department of Gastroenterology, Research Center for Infectious Diseases of Digestive System, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
J Family Med Prim Care. 2022 Sep;11(9):5495-5499. doi: 10.4103/jfmpc.jfmpc_2223_21. Epub 2022 Oct 14.
OBJECTIVE
Inflammatory markers are among the possible contributing factors with a proposed role in hepatic and ischemic heart disease. The present study aimed to determine the association between high-sensitivity-C-reactive protein (hs-CRP), liver elastography, and cardiac ischemic diseases in patients with fatty liver.
METHODS
In this cross-sectional comparative study, 103 consecutive patients with fatty liver were enrolled to undergo angiography. They were divided into groups with and without cardiac ischemia.
RESULTS
The results demonstrated that the mean hs-CRP was 2.3 and 10.9 mg/L in normal and ischemic angiography groups, respectively ( = 0.001). According to the receiver operating characteristic (ROC) analysis, the predictive role for hs-CRP was 94.5% that had sensitivity and specificity of 95.2% and 90%, respectively, with a cut-off point of 3.1.
CONCLUSION
This study showed that there is an association between the fatty liver, cardiac ischemia, and hs-CRP level.
目的
炎症标志物是可能导致肝脏疾病和缺血性心脏病的因素之一。本研究旨在确定脂肪肝患者中高敏C反应蛋白（hs-CRP）、肝脏弹性成像与心脏缺血性疾病之间的关联。
方法
在这项横断面比较研究中，连续纳入103例脂肪肝患者进行血管造影。他们被分为有心脏缺血和无心脏缺血两组。
结果
结果显示，正常血管造影组和缺血血管造影组的hs-CRP平均水平分别为2.3 mg/L和10.9 mg/L（P = 0.001）。根据受试者工作特征（ROC）分析，hs-CRP的预测作用为94.5%，其敏感性和特异性分别为95.2%和90%，截断点为3.1。
结论
本研究表明脂肪肝、心脏缺血与hs-CRP水平之间存在关联。
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