Viral Research Division, National Veterinary Research Institute, Vom, Nigeria.
Diagn Microbiol Infect Dis. 2010 Oct;68(2):163-5. doi: 10.1016/j.diagmicrobio.2010.05.015.
Highly pathogenic avian influenza (AI) is an infectious disease of agroeconomic and public health importance. The outbreak that occurred in Nigeria (2006-2008) was devastating to the poultry industry and raised public health concerns. In the course of its control, rapid laboratory confirmation of suspected cases in poultry was essential for prompt mobilization of control logistics for depopulation and decontamination of affected premises. Commercial rapid test kit was evaluated in the diagnosis of highly pathogenic AI (HPAI) as a preliminary to virus isolation. Between 2006 and 2007, 382 cases were tested out of which 149 were positive by rapid antigen detection. Virus isolation yielded 171 positive cases. The relative diagnostic sensitivity of Anigen Rapid AIV Ag test was 84.3% (95% confidence interval [CI], 78.1-88.9%), whereas the relative diagnostic specificity was 97.7% (95% CI, 94.2-99.1%). Rapid antigen detection is a useful technique for prompt diagnosis of HPAI for early detection and containment.
高致病性禽流感（AI）是一种具有农业经济和公共卫生重要性的传染病。2006-2008 年在尼日利亚发生的疫情对家禽业造成了毁灭性的打击，并引起了公众对健康问题的关注。在疫情控制过程中，迅速对家禽中的疑似病例进行实验室确认，对于及时调动控制物流以扑杀和消毒受感染场所至关重要。本研究评估了商业快速检测试剂盒在高致病性 AI（HPAI）诊断中的应用，作为病毒分离的初步检测方法。2006 年至 2007 年期间，共检测了 382 例病例，其中 149 例通过快速抗原检测呈阳性。病毒分离得到了 171 例阳性病例。Anigen Rapid AIV Ag 检测的相对诊断敏感性为 84.3%（95%置信区间[CI]，78.1-88.9%），相对诊断特异性为 97.7%（95%CI，94.2-99.1%）。快速抗原检测是一种用于早期检测和控制的快速诊断 HPAI 的有用技术。
