Department of Family Medicine, Min-Sheng General Hospital, Ching-Kuo Campus, Taoyuan, Taiwan.
Metabolism. 2011 Jun;60(6):799-804. doi: 10.1016/j.metabol.2010.07.031. Epub 2010 Sep 16.
U-shaped patterns have been observed for the relationship between sleep duration and diabetes. In addition, prediabetes is associated with the risk of cardiovascular diseases and diabetes. However, there are few studies investigating the relationship between sleep duration and prediabetes/newly diagnosed diabetes. The aim of this study is to examine the relationship between sleep duration and prediabetes/newly diagnosed diabetes in a Taiwanese population. After excluding the subjects with a high risk of obstructive sleep apnea, those with a positive history of diabetes, or those taking hypnotic drugs, a total of 3470 adults were recruited from a health checkup center. Each subject completed a self-administrated structured questionnaire on sleep duration and lifestyle factors. Prediabetes/diabetes was defined following the definition of the American Diabetes Association. Subjects with different sleep durations were classified into short (<6.0 hours), normal (6.0∼8.49 hours), and long sleepers (≥8.5 hours). The proportion of subjects with normal glucose tolerance, prediabetes, and newly diagnosed diabetes was 71.9%, 22.9%, and 5.2%, respectively. There were significant differences in age, sex, weight, education level, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure, alcohol and coffee drinking habits, family history of diabetes, and sleep duration among the 3 glycemic groups. In multinomial regression, both short and long sleepers had a higher risk of newly diagnosed diabetes; and the odds ratio were 1.55 (95% confidence interval, 1.07-2.24) and 2.83 (1.19-6.73), respectively. However, sleep duration was not found to relate to prediabetes. In conclusion, both short and long sleep durations were independently associated with newly diagnosed diabetes, but not with prediabetes.
U 型模式已经观察到睡眠持续时间与糖尿病之间的关系。此外，糖尿病前期与心血管疾病和糖尿病的风险相关。然而，很少有研究调查睡眠持续时间与糖尿病前期/新诊断的糖尿病之间的关系。本研究旨在探讨台湾人群中睡眠持续时间与糖尿病前期/新诊断的糖尿病之间的关系。在排除了阻塞性睡眠呼吸暂停高危人群、有糖尿病阳性病史或服用催眠药物的人群后，从健康检查中心共招募了 3470 名成年人。每位受试者都完成了一份关于睡眠持续时间和生活方式因素的自我管理结构化问卷。糖尿病前期/糖尿病根据美国糖尿病协会的定义进行定义。根据不同的睡眠时间将受试者分为短睡组（<6.0 小时）、正常组（6.0∼8.49 小时）和长睡组（≥8.5 小时）。正常糖耐量、糖尿病前期和新诊断糖尿病的受试者比例分别为 71.9%、22.9%和 5.2%。在 3 组血糖中，年龄、性别、体重、教育程度、体重指数、腰臀比、收缩压和舒张压、饮酒和喝咖啡习惯、糖尿病家族史和睡眠时间均有显著差异。在多变量回归中，短睡者和长睡者新发糖尿病的风险均较高；优势比分别为 1.55（95%可信区间，1.07-2.24）和 2.83（1.19-6.73）。然而，睡眠持续时间与糖尿病前期无关。总之，短睡和长睡均与新发糖尿病独立相关，但与糖尿病前期无关。
