Chaput Jean-Philippe, Després Jean-Pierre, Bouchard Claude, Astrup Arne, Tremblay Angelo
Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Sleep Med. 2009 Sep;10(8):919-24. doi: 10.1016/j.sleep.2008.09.016. Epub 2009 Mar 29.
To examine the long-term relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT).
Body composition measurements and self-reported sleep duration were determined in a longitudinal sample of 276 individuals aged 21 to 64 years followed for a mean of 6 years. Risk factors of type 2 diabetes/IGT over the follow-up were determined and relative risks (RRs) calculated for the development of type 2 diabetes/IGT by sleep duration group.
Independent risk factors of type 2 diabetes/IGT over the follow-up included age, obesity, sleep duration, and glucose/insulin homeostasis indicators. Using adults with 7-8h of sleep as a reference, the adjusted RR for the development of type 2 diabetes/IGT was 2.78 (1.61-4.12) for those with 6h of sleep and 2.54 (1.42-3.53) for those with 9h of sleep. These elevated RRs remained significant after adjustment for body mass index, waist circumference or percent body fat.
Short and long sleeping times are associated with a higher risk of developing type 2 diabetes/IGT, independent of several covariates. These results suggest that sleep duration may represent a novel risk factor for type 2 diabetes/IGT.
研究睡眠时间与2型糖尿病或糖耐量受损（IGT）之间的长期关系。
对276名年龄在21至64岁之间的个体进行纵向抽样，测量其身体成分并自我报告睡眠时间，平均随访6年。确定随访期间2型糖尿病/IGT的危险因素，并计算不同睡眠时间组发生2型糖尿病/IGT的相对风险（RRs）。
随访期间2型糖尿病/IGT的独立危险因素包括年龄、肥胖、睡眠时间以及血糖/胰岛素稳态指标。以睡眠时间为7 - 8小时的成年人作为参照，睡眠时间为6小时的人群发生2型糖尿病/IGT的校正RR为2.78（1.61 - 4.12），睡眠时间为9小时的人群为2.54（1.42 - 3.53）。在对体重指数、腰围或体脂百分比进行校正后，这些升高的RRs仍具有显著性。
睡眠时间过短和过长均与发生2型糖尿病/IGT的较高风险相关，且独立于多个协变量。这些结果表明，睡眠时间可能是2型糖尿病/IGT的一个新的危险因素。
