Pierchalla A, Schulte K W, Homey B
Hautklinik der Heinrich-Heine-Universität, Moorenstr. 5, 40225, Düsseldorf.
Hautarzt. 2010 Oct;61(10):834-6. doi: 10.1007/s00105-010-2047-z.
Linear localized scleroderma is a variant of localized scleroderma characterized by linear bands and sclerotic plaques of the skin, which can result in contractures, muscle atrophy and debilitating deformities. The etiology remains unknown and no specific therapy is available. Regimens combining pulsed high-dose corticosteroids with methotrexate therapy seem promising. Our patient responded well to intravenous prednisolone (500 mg/d) for 3 consecutive days monthly combined with an oral dose of methotrexate of (15 mg/wk).
线性局限性硬皮病是局限性硬皮病的一种变体，其特征为皮肤出现线性条带和硬化斑块，可导致挛缩、肌肉萎缩和致残性畸形。病因尚不清楚，且尚无特效疗法。将大剂量脉冲式皮质类固醇与甲氨蝶呤联合使用的治疗方案似乎很有前景。我们的患者对每月连续3天静脉注射泼尼松龙（500毫克/天）并联合口服甲氨蝶呤（15毫克/周）反应良好。
