Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
J Dermatol. 2010 Jan;37(1):75-80. doi: 10.1111/j.1346-8138.2009.00750.x.
The patient was a 12-year-old girl with linear scleroderma distributed on the right abdomen, dorsal aspect of the right thigh, lower leg and foot. The initial regimen of oral prednisolone and methotrexate, or i.v. methylprednisolone failed in the treatment of the scleroderma. Then bath psoralen and ultraviolet A therapy (bath-PUVA) therapy of 0.2 J-4.0 J/cm(2) daily to total doses 62.8 J/cm(2) combined with oral prednisolone was started. After bath-PUVA therapy, regression of the skin sclerosis was observed, the possible mobile range of the right ankle was increased and histological examination confirmed improvement of the sclerosis. The successful results of bath-PUVA therapy in this case suggest its utility for localized scleroderma.
患者为 12 岁女孩，右侧腹部、右大腿背侧、小腿及足部可见线状硬皮病。初始治疗方案为口服泼尼松龙和甲氨蝶呤，或静脉注射甲基泼尼松龙，但治疗硬皮病无效。随后，开始每日给予 0.2 J-4.0 J/cm(2) 总剂量 62.8 J/cm(2)的补骨脂素光化学疗法（bath-PUVA）联合口服泼尼松龙治疗。bath-PUVA 治疗后，皮肤硬化消退，右踝关节活动度可能增加，组织学检查证实硬化改善。该病例 bath-PUVA 治疗成功，提示其对局限性硬皮病有效。
