Douglas Mental Health University Institute, McGill University, 6875, LaSalle Boulevard, Montreal, QC, H4H 1R3, Canada.
Soc Psychiatry Psychiatr Epidemiol. 2011 Nov;46(11):1173-9. doi: 10.1007/s00127-010-0284-1. Epub 2010 Sep 17.
Recent cross-sectional findings suggest that co-occurring obesity and psychological problems amplify the risk of disability, but longitudinal evidence is lacking. We assessed this effect in a longitudinal cohort of adults.
Twelve years of data (1994/1995-2006/2007) were obtained from the Canadian National Population Health Survey. This study followed 8,062 adults that were interviewed every 2 years. Disability status was derived from the Health Utility Index Mark 3. Covariates of interest were repeated psychological distress (Kessler K6 scale) and obesity (body mass index ≥30). Incidence of disability was estimated from Cox proportional hazards models, adjusting for sociodemographic and health variables. Hazard rate of disability in those with either obesity (n = 955) or distress (n = 1,044), or both (n = 138) were compared to those without (n = 5,925).
Participants with both obesity and repeated distress had double the risk of disability compared to those with obesity or distress alone {adjusted hazard ratio of 2.8 [95% confidence interval (CI) 1.8, 4.5] compared to 1.4 (CI 1.1, 1.8) and 1.8 (CI 1.4, 2.3), respectively}.
Recurrent psychological distress combined with obesity amplified the risk for disability normally associated with these conditions.
最近的横断面研究结果表明，肥胖和心理问题同时存在会放大残疾的风险，但缺乏纵向证据。我们在一个成年人的纵向队列中评估了这种影响。
从加拿大国家人口健康调查中获得了 12 年的数据（1994/1995 年至 2006/2007 年）。本研究随访了 8062 名每两年接受一次访谈的成年人。残疾状况来自健康效用指数 Mark 3。感兴趣的协变量为反复出现的心理困扰（Kessler K6 量表）和肥胖（体重指数≥30）。使用 Cox 比例风险模型从残疾的发生率中估计，调整了社会人口统计学和健康变量。在那些有肥胖（n=955）或心理困扰（n=1044）或两者都有的（n=138）的人中，残疾的风险率与没有（n=5925）的人进行了比较。
与肥胖或仅有心理困扰的患者相比，同时患有肥胖和反复出现心理困扰的患者残疾的风险增加了一倍（调整后的危险比为 2.8[95%置信区间（CI）1.8，4.5]，而 1.4（CI 1.1，1.8）和 1.8（CI 1.4，2.3））。
反复出现的心理困扰加上肥胖会放大这些疾病通常与残疾相关的风险。
