Marinkovic Serge P, Gillen Lisa M, Marinkovic Christina M
Department of Urology and Urogynecology, Women's and Children's Hospital, Lafayette, LA 70508, USA.
Int Urogynecol J. 2011 Apr;22(4):407-12. doi: 10.1007/s00192-010-1235-9. Epub 2010 Sep 17.
Interstitial cystitis is a multifaceted medical condition consisting of pelvic pain, urgency, and frequency. Can sacral neuromodulation be successfully utilized for the medium term of ≥ 6 years in interstitial cystitis patients for whom standard drug therapies have failed?
In our observational, retrospective, case-controlled review (January 2002-March 2004), we sought to discern whether neuromodulation could be successfully implemented with acceptable morbidity rates in interstitial cystitis patients. Thirty-four female patients underwent stage 1 and 2 InterStim placements under a general anesthetic. Simple means and medians were analyzed.
Mean pre-op/post-op pelvic pain and urgency/frequency scores were 21.61 ± 8.6/9.22 ± 6.6 (p < 0.01), and mean pre-op/post-op visual analog pain scale (VAPS) were 6.5 ± 2.9/2.4 ± 1.1 (p < 0.01). Median age was 41 ± 14.8 years with a mean follow-up of 86 ± 9.8 months.
With a minimum 6-year follow-up we determined that sacral neuromodulation provides adequate improvement for the symptoms of recalcitrant interstitial cystitis.
间质性膀胱炎是一种多方面的医学病症，包括盆腔疼痛、尿急和尿频。对于标准药物治疗无效的间质性膀胱炎患者，骶神经调节能否在≥6年的中期成功应用？
在我们的观察性、回顾性、病例对照研究（2002年1月至2004年3月）中，我们试图确定在间质性膀胱炎患者中能否以可接受的发病率成功实施神经调节。34名女性患者在全身麻醉下接受了第1阶段和第2阶段的InterStim植入。分析了简单均值和中位数。
术前/术后盆腔疼痛和尿急/尿频的平均评分分别为21.61±8.6/9.22±6.6（p<0.01），术前/术后视觉模拟疼痛量表（VAPS）的平均评分分别为6.5±2.9/2.4±1.1（p<0.01）。中位年龄为41±14.8岁，平均随访86±9.8个月。
经过至少6年的随访，我们确定骶神经调节可为顽固性间质性膀胱炎的症状提供充分改善。
