Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Inflamm Bowel Dis. 2010 Nov;16(11):1957-62. doi: 10.1002/ibd.21277.
A few cross-sectional studies reported an increased risk of inflammatory bowel disease (IBD) among asthmatics. We conducted a population-based, case-control study that applied predetermined criteria for asthma and IBD to determine whether asthma, as a T-helper 2 (Th2) condition, reduces the risk of IBD, a Th1 condition.
This was a population-based, case-control study using criteria-based ascertainment for IBD and asthma. Subjects were all Rochester, Minnesota, residents who had developed IBD between 1964 and 1983 and their age- and gender-matched controls, using 1:1 matching. Controls were randomly selected from the community using the Rochester Epidemiology Project database and confirmed not to have IBD. All cases and controls were merged with the database comprising all Rochester residents with or without asthma between 1964 and 1983.
Of the 231 IBD cases, 55% had ulcerative colitis and the remainder had Crohn's disease. Of these, 50.4% were male and 98.1% were Caucasians. The mean age at the time of IBD diagnosis was 33.8 years. Four cases (1.7%) had asthma prior to the index date of IBD, whereas two controls (0.9%) had asthma (unadjusted odds ratio [OR]: 3.0, 95% confidence interval [CI]: 0.31-28.84, P = 0.34). Similarly, 16 IBD cases (6.9%) had asthma ever while 12 controls (5.2%) had asthma ever (unadjusted OR: 1.4, 95% CI: 0.62-3.38, P = 0.40).
Asthma as a Th2 condition does not reduce the risk of IBD as a Th1 condition. Because of the limitations of our study and others, the association between asthma and IBD needs to be further studied.
一些横断面研究报告称哮喘患者发生炎症性肠病（IBD）的风险增加。我们进行了一项基于人群的病例对照研究，应用哮喘和 IBD 的既定标准来确定哮喘作为 T 辅助 2（Th2）疾病是否会降低 Th1 疾病 IBD 的风险。
这是一项基于人群的病例对照研究，使用基于标准的方法确定 IBD 和哮喘。研究对象均为明尼苏达州罗切斯特市的居民，他们在 1964 年至 1983 年间患有 IBD，并按年龄和性别与 1:1 匹配的对照组相匹配。对照组通过罗切斯特流行病学项目数据库随机选择，且确认未患有 IBD。所有病例和对照均与 1964 年至 1983 年间具有或不具有哮喘的所有罗切斯特居民数据库合并。
在 231 例 IBD 病例中，55%患有溃疡性结肠炎，其余患者患有克罗恩病。其中，50.4%为男性，98.1%为白种人。IBD 诊断时的平均年龄为 33.8 岁。4 例（1.7%）在 IBD 发病前有哮喘，而 2 例（0.9%）对照有哮喘（未调整比值比[OR]：3.0，95%置信区间[CI]：0.31-28.84，P=0.34）。同样，16 例 IBD 病例（6.9%）曾患有哮喘，而 12 例对照（5.2%）曾患有哮喘（未调整 OR：1.4，95% CI：0.62-3.38，P=0.40）。
作为 Th2 疾病的哮喘并不能降低作为 Th1 疾病的 IBD 的风险。由于我们研究和其他研究的局限性，哮喘和 IBD 之间的关联需要进一步研究。
