• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

癌组织中细胞外基质金属蛋白酶诱导因子（EMMPRIN）过表达的临床病理意义及预后价值：来自39项队列研究的证据

The clinicopathological significance and prognostic value of EMMPRIN overexpression in cancers: evidence from 39 cohort studies.

作者信息

Fan Hengwei, Yi Wanwan, Wang Chenxing, Wang Jisheng

机构信息

Department of Hepatobiliary Surgery, The 2nd Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Zhejiang 325027, China.

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.

出版信息

Oncotarget. 2017 Jul 31;8(47):82643-82660. doi: 10.18632/oncotarget.19740. eCollection 2017 Oct 10.

DOI:10.18632/oncotarget.19740
PMID:29137291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5669917/
Abstract

Extracellular matrix metalloproteinase inducer (EMMPRIN) has been reported to be associated with tumor formation and invasion in many studies. However, the clinicopathological significance and prognosis of EMMPRIN in cancer patients remains inconclusive. Therefore, we conducted a meta-analysis to assess the predictive potential of EMMPRIN in various cancers. By searching Pubmed, Cochrane library database and web of science comprehensively, 39studies with 5739 cases were included in our meta-analysis. The results indicated that EMMPRIN overexpression was significantly associated with poor outcome of cancers (HR=2.46, 95% CI: 2.21-2.75, P<0.0001). In addition, a significant relation was found between EMMPRIN overexpression and clinicopathological features, such as tumor stage (T3+T4/ T1+T2, OR=1.87, 95% CI:1.64-2.12, P<0.0001), tumor differentiation (poor/ well+ moderate, OR=1.09, 95% CI:1.60-2.23, P<0.0001), clinical stage (III+IV /I +II, OR=1.96, 95% CI:1.69-2.27, P<0.0001) and nodal metastasis (positive/negative, OR=2.37, 95% CI:1.93-2.90, P<0.0001). However, the expression of EMMRIN was not significantly associated with tumor stage in cervical cancer (OR=1.35, 95%CI: 0.73-2.48, P=0.33). In conclusion, EMMPRIN overxepression is significantly associated with clinicopathological characteristics and prognosis of cancers. Thus, EMMPRIN may be regarded as a promising bio-marker in predicting the clinical outcome of patients in cancers and could be used as the therapeutic target during clinical practices.

摘要

在许多研究中，细胞外基质金属蛋白酶诱导剂（EMMPRIN）已被报道与肿瘤形成和侵袭有关。然而，EMMPRIN在癌症患者中的临床病理意义和预后仍无定论。因此，我们进行了一项荟萃分析，以评估EMMPRIN在各种癌症中的预测潜力。通过全面检索PubMed、Cochrane图书馆数据库和科学网，我们的荟萃分析纳入了39项研究，共5739例病例。结果表明，EMMPRIN过表达与癌症患者的不良预后显著相关（HR=2.46，95%CI：2.21-2.75，P<0.0001）。此外，还发现EMMPRIN过表达与临床病理特征之间存在显著关系，如肿瘤分期（T3+T4/T1+T2，OR=1.87，95%CI：1.64-2.12，P<0.0001）、肿瘤分化（差/好+中等，OR=1.09，95%CI：1.60-2.23，P<0.0001）、临床分期（III+IV/I+II，OR=1.96，95%CI：1.69-2.27，P<0.0001）和淋巴结转移（阳性/阴性，OR=2.37，95%CI：1.93-2.90，P<0.0001）。然而，EMMRIN的表达与宫颈癌的肿瘤分期无显著相关性（OR=1.35，95%CI：0.73-2.48，P=0.33）。总之，EMMPRIN过表达与癌症的临床病理特征和预后显著相关。因此，EMMPRIN可被视为预测癌症患者临床结局的有前景的生物标志物，并可在临床实践中用作治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/3858ba271068/oncotarget-08-82643-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/478734d48ed1/oncotarget-08-82643-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/4109778ed725/oncotarget-08-82643-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/42c42347b76f/oncotarget-08-82643-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/cc9a07d65214/oncotarget-08-82643-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/85cf54deb784/oncotarget-08-82643-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/9b121deb5ea9/oncotarget-08-82643-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/1ef2bf66151c/oncotarget-08-82643-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/f39c0eb8d59d/oncotarget-08-82643-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/04d945f46b78/oncotarget-08-82643-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/a179abe2ca53/oncotarget-08-82643-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/3858ba271068/oncotarget-08-82643-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/478734d48ed1/oncotarget-08-82643-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/4109778ed725/oncotarget-08-82643-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/42c42347b76f/oncotarget-08-82643-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/cc9a07d65214/oncotarget-08-82643-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/85cf54deb784/oncotarget-08-82643-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/9b121deb5ea9/oncotarget-08-82643-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/1ef2bf66151c/oncotarget-08-82643-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/f39c0eb8d59d/oncotarget-08-82643-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/04d945f46b78/oncotarget-08-82643-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/a179abe2ca53/oncotarget-08-82643-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe8/5669917/3858ba271068/oncotarget-08-82643-g011.jpg

相似文献

1
The clinicopathological significance and prognostic value of EMMPRIN overexpression in cancers: evidence from 39 cohort studies.癌组织中细胞外基质金属蛋白酶诱导因子（EMMPRIN）过表达的临床病理意义及预后价值：来自39项队列研究的证据
Oncotarget. 2017 Jul 31;8(47):82643-82660. doi: 10.18632/oncotarget.19740. eCollection 2017 Oct 10.
2
EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer.宫颈癌放疗中作为预后因素的细胞外基质金属蛋白酶诱导因子表达
Clin Cancer Res. 2008 Jan 15;14(2):494-501. doi: 10.1158/1078-0432.CCR-07-1072.
3
Prognostic role of extracellular matrix metalloproteinase inducer/CD147 in gastrointestinal cancer: a meta-analysis of related studies.细胞外基质金属蛋白酶诱导剂/CD147在胃肠道癌中的预后作用：相关研究的Meta分析
Oncotarget. 2016 Dec 6;7(49):81003-81011. doi: 10.18632/oncotarget.12745.
4
CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis.CD147/EMMPRIN 过表达与癌症预后：系统评价和荟萃分析。
Sci Rep. 2016 Sep 9;6:32804. doi: 10.1038/srep32804.
5
High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological parameters.细胞外基质金属蛋白酶诱导剂在非小细胞肺癌中的高表达。与临床病理参数的关系。
Oncology. 2007;72(3-4):197-204. doi: 10.1159/000112826. Epub 2007 Dec 21.
6
The clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: a meta-analysis of literature.胃癌患者HER2表达的临床病理参数及预后意义：文献荟萃分析
World J Surg Oncol. 2017 Mar 21;15(1):68. doi: 10.1186/s12957-017-1132-5.
7
Expression of extracellular matrix metalloproteinase inducer and fascin in urinary bladder cancer: Correlation with clinicopathological characteristics.细胞外基质金属蛋白酶诱导剂和细丝蛋白在膀胱癌中的表达：与临床病理特征的相关性
Mol Clin Oncol. 2013 Mar;1(2):297-304. doi: 10.3892/mco.2013.57. Epub 2013 Jan 2.
8
Upregulated expression of ADAM17 is a prognostic marker for patients with gastric cancer.ADAM17 的高表达是胃癌患者的预后标志物。
Ann Surg. 2012 Dec;256(6):1014-22. doi: 10.1097/SLA.0b013e3182592f56.
9
Prognostic Values of Vimentin Expression and Its Clinicopathological Significance in Non-Small Cell Lung Cancer: A Meta-Analysis of Observational Studies with 4118 Cases.波形蛋白表达在非小细胞肺癌中的预后价值及其临床病理意义：一项纳入4118例病例的观察性研究的荟萃分析
PLoS One. 2016 Sep 22;11(9):e0163162. doi: 10.1371/journal.pone.0163162. eCollection 2016.
10
Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis.生存素过表达与宫颈癌侵袭性临床病理特征相关：一项Meta分析
PLoS One. 2016 Oct 20;11(10):e0165117. doi: 10.1371/journal.pone.0165117. eCollection 2016.

引用本文的文献

1
EMMPRIN Correlated with β-CATENIN in Various t Stages of Colorectal Adenocarcinoma.在结直肠癌不同t分期中，细胞外基质金属蛋白酶诱导因子与β-连环蛋白相关。
Asian Pac J Cancer Prev. 2025 Mar 1;26(3):1001-1007. doi: 10.31557/APJCP.2025.26.3.1001.
2
Role of CD147 in the development and diagnosis of hepatocellular carcinoma.CD147 在肝细胞癌发生发展及诊断中的作用。
Front Immunol. 2023 Apr 6;14:1149931. doi: 10.3389/fimmu.2023.1149931. eCollection 2023.
3
Changes in the Extracellular Matrix in Endometrial and Cervical Cancer: A Systematic Review.

本文引用的文献

1
Cancer statistics, 2016.癌症统计数据，2016 年。
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: 10.3322/caac.21332. Epub 2016 Jan 7.
2
Prognostic value of melanoma cell adhesion molecule expression in cancers: a meta-analysis.黑色素瘤细胞粘附分子表达在癌症中的预后价值：一项荟萃分析。
Int J Clin Exp Med. 2015 Aug 15;8(8):12056-63. eCollection 2015.
3
MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma.在透明细胞肾细胞癌中，单羧酸转运蛋白4（MCT4）的预后相关性超过了辅助蛋白CD147。
子宫内膜癌和宫颈癌中细胞外基质的变化：系统评价。
Int J Mol Sci. 2023 Mar 13;24(6):5463. doi: 10.3390/ijms24065463.
4
Advanced T and Natural Killer Cell Therapy for Glioblastoma.用于胶质母细胞瘤的先进T细胞和自然杀伤细胞疗法。
J Korean Neurosurg Soc. 2023 Jul;66(4):356-381. doi: 10.3340/jkns.2022.0267. Epub 2023 Jan 2.
5
Interstitial collagenase MMP-1 and EMMPRIN in cell lines and in clinical specimens of cervical squamous cell carcinoma.间质胶原酶 MMP-1 和 EMMPRIN 在宫颈鳞癌细胞系和临床标本中的表达。
Mol Biol Rep. 2021 Oct;48(10):6879-6886. doi: 10.1007/s11033-021-06689-z. Epub 2021 Sep 8.
6
CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker.CD147是肿瘤进展的一个有前景的靶点及一种预后生物标志物。
Cancers (Basel). 2019 Nov 16;11(11):1803. doi: 10.3390/cancers11111803.
Oncotarget. 2015 Oct 13;6(31):30615-27. doi: 10.18632/oncotarget.5593.
4
Overexpression of MMP Family Members Functions as Prognostic Biomarker for Breast Cancer Patients: A Systematic Review and Meta-Analysis.MMP家族成员的过表达作为乳腺癌患者的预后生物标志物：一项系统评价和荟萃分析
PLoS One. 2015 Aug 13;10(8):e0135544. doi: 10.1371/journal.pone.0135544. eCollection 2015.
5
High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.PKM2高表达作为一种预后不良指标与宫颈癌的放射抗性相关。
Histol Histopathol. 2015 Nov;30(11):1313-20. doi: 10.14670/HH-11-627. Epub 2015 May 4.
6
CD147 and Ki-67 overexpression confers poor prognosis in squamous cell carcinoma of oral tongue: a tissue microarray study.CD147和Ki-67过表达提示舌鳞状细胞癌预后不良：一项组织芯片研究
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 May;119(5):553-65. doi: 10.1016/j.oooo.2014.12.022. Epub 2015 Jan 7.
7
Predicting cancer prognosis using functional genomics data sets.使用功能基因组数据集预测癌症预后。
Cancer Inform. 2014 Nov 2;13(Suppl 5):85-8. doi: 10.4137/CIN.S14064. eCollection 2014.
8
Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period.ACE、AKR1C2、FTO 和 MMP2 多态性与 10 年间体重增加的性别特异性遗传关联。
Genes Nutr. 2014 Nov;9(6):434. doi: 10.1007/s12263-014-0434-2. Epub 2014 Oct 17.
9
Hepatocellular carcinoma tumour markers: current role and expectations.肝细胞癌肿瘤标志物：当前作用与期望
Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):843-53. doi: 10.1016/j.bpg.2014.07.018. Epub 2014 Aug 22.
10
CD147 expression in human gastric cancer is associated with tumor recurrence and prognosis.CD147在人胃癌中的表达与肿瘤复发及预后相关。
PLoS One. 2014 Jun 30;9(6):e101027. doi: 10.1371/journal.pone.0101027. eCollection 2014.