Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chemosphere. 2010 Nov;81(8):1027-32. doi: 10.1016/j.chemosphere.2010.08.050. Epub 2010 Sep 17.
Metabolic syndrome (MetS) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease. There is a positive correlation between exposure to persistent organic pollutants and MetS. We examine the association between PCDD/Fs and MetS components in 1490 non-diabetic persons living near a highly dioxin-contaminated area. We used factor analysis, with a set of core variables considered central features of MetS and PCDD/Fs, to group similar risk factors. Serum PCDD/Fs were positively and significantly correlated with the number of MetS components. Four risk factors-lipidemia, blood pressure, body size, and glycemia-accounted for 72.6% of the variance in the 10 core factors, and PCDD/Fs were linked to MetS through shared correlations with high blood pressure. After adjusting for confounding factors, we found that diastolic blood pressure (β=0.018; p=0.006), glucose (β=0.013; p=0.046), and waist circumference (β=0.721; p=0.042) significantly increased with increasing serum PCDD/F levels. We found significant trends for associations between metabolic syndrome and serum low-chlorinated PCDD/Fs. The highest quintiles of 2,3,4,7,8-PeCDF, 1,2,3,6,7,8-HxCDF and 2,3,7,8-TCDD had the top three adjusted ORs (95% CI) of 3.5 (1.9-6.3), 2.9 (1.7-4.9) and 2.8 (1.6-4.9), respectively. We also found a slight monotonic relationship between serum PCDD/Fs and the prevalence of MetS, especially when the serum dioxin level was higher than 25.4pg WHO(98)-TEQ(DF)g(-1) lipid (the fourth Quintile). We hypothesize that high-dose exposure to PCDD/Fs is a blood pressure-related factor that raises MetS risk.
代谢综合征（MetS）由一系列代谢异常组成，这些异常会增加心血管疾病的风险。接触持久性有机污染物与 MetS 之间存在正相关关系。我们在 1490 名居住在高度二恶英污染地区附近的非糖尿病患者中研究了 PCDD/Fs 与 MetS 成分之间的关联。我们使用因子分析，使用一组被认为是 MetS 和 PCDD/Fs 核心特征的核心变量来对相似的危险因素进行分组。血清 PCDD/Fs 与 MetS 成分的数量呈正相关且显著相关。四个危险因素——血脂、血压、体型和血糖——解释了 10 个核心因素中 72.6%的方差，PCDD/Fs 通过与高血压的共同相关性与 MetS 相关。在调整混杂因素后，我们发现舒张压（β=0.018；p=0.006）、血糖（β=0.013；p=0.046）和腰围（β=0.721；p=0.042）随着血清 PCDD/F 水平的升高而显著增加。我们发现代谢综合征与血清低氯代 PCDD/Fs 之间存在显著的关联趋势。2,3,4,7,8-PeCDF、1,2,3,6,7,8-HxCDF 和 2,3,7,8-TCDD 的最高五分位数具有最高的调整后比值比（95%CI）分别为 3.5（1.9-6.3）、2.9（1.7-4.9）和 2.8（1.6-4.9）。我们还发现血清 PCDD/Fs 与 MetS 的患病率之间存在轻微的单调关系，尤其是当血清二恶英水平高于 25.4pg WHO(98)-TEQ(DF)g(-1)脂质（第四五分位数）时。我们假设，高剂量接触 PCDD/Fs 是一种与血压相关的因素，会增加 MetS 的风险。
