School of Biological Sciences and Institute of Microbiology, Seoul National University, Gwanak 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
Curr Opin Microbiol. 2010 Oct;13(5):646-51. doi: 10.1016/j.mib.2010.08.007. Epub 2010 Sep 17.
Vibrio cholera, the causal agent of cholera, also occupies an autochthonous aquatic inhabitant. The current, seventh cholera pandemic is linked to O1 El Tor biotype and O139 serogroups. In the last decades, we have witnessed a shift involving genetically and phenotypically varied pandemic clones in Asia and Africa. Recent comparative genomic studies have identified a large 'mobilome', or composed of mobile genomic islands in V. cholerae. All seventh pandemic isolates have highly related genome sequences, but they can be differentiated by set of these genomic islands. A consequence of the extensive lateral gene transfer is that classically important diagnostic markers, such as serotype and biotype, are not reliable and new methods based on genomic sequences are required.
霍乱弧菌是霍乱的病原体，也是一种本土水生生物。目前的第七次霍乱大流行与 O1 型埃尔托生物型和 O139 血清群有关。在过去的几十年里，我们见证了亚洲和非洲的基因和表型多样化的流行克隆的转变。最近的比较基因组研究鉴定了一个大型的“可移动基因组”，或由霍乱弧菌中的移动基因组岛组成。所有第七次大流行的分离株都具有高度相关的基因组序列，但可以通过一组这些基因组岛来区分。广泛的水平基因转移的结果是，经典的重要诊断标志物，如血清型和生物型，不再可靠，需要基于基因组序列的新方法。
