结节病与慢性丙型肝炎：泼尼松与秋水仙碱治疗

Pereira Eduardo Guimarães, Guimarães Tais Ferreira, Bottino Caroline Bertolini, D'Acri Antonio Macedo, Lima Ricardo Barbosa, Martins Carlos José

Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

An Bras Dermatol. 2016 Apr;91(2):231-4. doi: 10.1590/abd1806-4841.20164029.

Sarcoidosis is a disease which still has uncertain etiology. Possible environmental causes are cited in the literature, like organic and inorganic particles and infectious agents. Recent studies have demonstrated the occurrence of sarcoidosis in patients with chronic C hepatitis; however, this association remains without statistical or causal evidence. In this report a case of sarcoidosis associated with chronic hepatitis C will be described, with subcutaneous lesions, considered rare, and good response to treatment with colchicine and prednisone. The hepatitis C virus was isolated in sarcoid tissue and the association between the two diseases will be discussed.

结节病是一种病因仍不明确的疾病。文献中列举了可能的环境病因，如有机和无机颗粒以及感染因子。最近的研究已证实在慢性丙型肝炎患者中会出现结节病；然而，这种关联仍缺乏统计学或因果证据。在本报告中，将描述一例与慢性丙型肝炎相关的结节病病例，该病例伴有皮下病变，这种情况较为罕见，且对秋水仙碱和泼尼松治疗反应良好。在结节病组织中分离出了丙型肝炎病毒，并将讨论这两种疾病之间的关联。