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结节病与慢性丙型肝炎:泼尼松与秋水仙碱治疗

Sarcoidosis and chronic hepatitis C: treatment with prednisone and colchicine.

作者信息

Pereira Eduardo Guimarães, Guimarães Tais Ferreira, Bottino Caroline Bertolini, D'Acri Antonio Macedo, Lima Ricardo Barbosa, Martins Carlos José

机构信息

Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

出版信息

An Bras Dermatol. 2016 Apr;91(2):231-4. doi: 10.1590/abd1806-4841.20164029.

DOI:10.1590/abd1806-4841.20164029
PMID:27192527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4861575/
Abstract

Sarcoidosis is a disease which still has uncertain etiology. Possible environmental causes are cited in the literature, like organic and inorganic particles and infectious agents. Recent studies have demonstrated the occurrence of sarcoidosis in patients with chronic C hepatitis; however, this association remains without statistical or causal evidence. In this report a case of sarcoidosis associated with chronic hepatitis C will be described, with subcutaneous lesions, considered rare, and good response to treatment with colchicine and prednisone. The hepatitis C virus was isolated in sarcoid tissue and the association between the two diseases will be discussed.

摘要

结节病是一种病因仍不明确的疾病。文献中列举了可能的环境病因,如有机和无机颗粒以及感染因子。最近的研究已证实在慢性丙型肝炎患者中会出现结节病;然而,这种关联仍缺乏统计学或因果证据。在本报告中,将描述一例与慢性丙型肝炎相关的结节病病例,该病例伴有皮下病变,这种情况较为罕见,且对秋水仙碱和泼尼松治疗反应良好。在结节病组织中分离出了丙型肝炎病毒,并将讨论这两种疾病之间的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcb/4861575/f00fcc75d7c6/abd-91-02-0231-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcb/4861575/ae28c4fcdf8f/abd-91-02-0231-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcb/4861575/6218d47f8b37/abd-91-02-0231-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcb/4861575/f00fcc75d7c6/abd-91-02-0231-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcb/4861575/ae28c4fcdf8f/abd-91-02-0231-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcb/4861575/6218d47f8b37/abd-91-02-0231-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcb/4861575/f00fcc75d7c6/abd-91-02-0231-g03.jpg

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引用本文的文献

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Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome.秋水仙碱治疗与 COVID-19 肺炎和急性呼吸窘迫综合征住院成年患者生存改善的相关性:单中心队列研究。
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本文引用的文献

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Sarcoidosis: a comprehensive review and update for the dermatologist: part I. Cutaneous disease.结节病:皮肤科医生的全面综述和更新:第一部分。皮肤疾病。
J Am Acad Dermatol. 2012 May;66(5):699.e1-18; quiz 717-8. doi: 10.1016/j.jaad.2011.11.965.
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Subcutaneous sarcoidosis: report of two cases and review of the literature.皮下结节性脂膜炎:两例报告并文献复习。
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Development of sarcoidosis following completion of treatment for hepatitis C with pegylated interferon-{alpha}2a and ribavirin: a case report and literature review.
Why not to use colchicine in COVID-19? An oldanti-inflammatory drug for a novel auto-inflammatory disease.
为何不在新冠肺炎治疗中使用秋水仙碱?一种用于新型自身炎症性疾病的古老抗炎药物。
Rheumatology (Oxford). 2020 Jul 1;59(7):1769-1770. doi: 10.1093/rheumatology/keaa217.
聚乙二醇化干扰素-α2a联合利巴韦林治疗丙型肝炎后发生结节病:1例报告及文献复习
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Sarcoidosis and hepatitis C: clinical description of 11 cases.结节病和丙型肝炎:11 例临床描述。
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Clinical resolution of facial cutaneous sarcoidosis with systemic colchicine and a topical corticosteroid ointment.面部皮肤结节病经全身性秋水仙碱和外用皮质类固醇软膏治疗后的临床缓解
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Lichen planus and other cutaneous manifestations in chronic hepatitis C: pre- and post-interferon-based treatment prevalence vary in a cohort of patients from low hepatitis C virus endemic area.慢性丙型肝炎中的扁平苔藓及其他皮肤表现:来自丙型肝炎病毒低流行地区的一组患者在基于干扰素治疗前后的患病率有所不同。
J Eur Acad Dermatol Venereol. 2008 Jul;22(7):779-88. doi: 10.1111/j.1468-3083.2008.02676.x. Epub 2008 Apr 29.
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Sarcoidosis.结节病
N Engl J Med. 2007 Nov 22;357(21):2153-65. doi: 10.1056/NEJMra071714.
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Sarcoidosis in patients with chronic hepatitis C virus infection: analysis of 68 cases.慢性丙型肝炎病毒感染患者的结节病:68例分析。
Medicine (Baltimore). 2005 Mar;84(2):69-80. doi: 10.1097/01.md.0000157577.69729.e6.
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Detection of hepatitis C virus RNA and core protein in keratinocytes from patients with cutaneous lichen planus and chronic hepatitis C.皮肤扁平苔藓和慢性丙型肝炎患者角质形成细胞中丙型肝炎病毒RNA和核心蛋白的检测
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