CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Nat Struct Mol Biol. 2010 Oct;17(10):1266-8. doi: 10.1038/nsmb.1909. Epub 2010 Sep 19.
Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.
根据其一级结构,甲型流感病毒神经氨酸酶可分为 1 组和 2 组。1 组神经氨酸酶的主要结构特征是活性部位的一个额外腔,即 150 腔。在这里,我们展示了来自 2009 年大流行 H1N1 流感株的神经氨酸酶的晶体结构。与其他已鉴定的 N1 神经氨酸酶不同,它们都是 1 组的成员,2009 年 H1N1 神经氨酸酶没有 150 腔。