Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Science. 2010 Apr 16;328(5976):357-60. doi: 10.1126/science.1186430. Epub 2010 Mar 25.
The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.
2009 年 H1N1 猪流感是几十年来的第一次流感大流行。A/California/04/2009 H1N1 病毒血凝素的晶体结构表明，其抗原结构，特别是在 Sa 抗原位点，与 20 世纪初流行的人类 H1N1 病毒极其相似。与 2D1 的 1918 年血凝素共结晶，2D1 是一位经历过 1918 年西班牙流感幸存者的抗体，能够中和 1918 年和 2009 年的 H1N1 病毒，揭示了一个在两种大流行病毒中都保守的表位。因此，2009 年和类似 1918 年的病毒之间的抗原相似性为当前流感大流行的年龄相关免疫提供了一个解释。
