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牛疱疹病毒 4 基因组整合到培养的持续性感染宿主细胞基因组中。

Integration of bovine herpesvirus 4 genome into cultured persistently infected host cell genome.

机构信息

Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Università di Parma, Via del Taglio 10, 43100 Parma, Italy.

出版信息

Virol J. 2010 Sep 21;7:246. doi: 10.1186/1743-422X-7-246.

DOI:10.1186/1743-422X-7-246
PMID:20854697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2949847/
Abstract

Persistent infection of macrophages with bovine herpesvirus 4 (BoHV-4) has been proposed to play a secondary causal role, along with bacterial infection, in bovine post-partum metritis. Mechanisms of maintenance of BoHV-4 persistent infection are not understood. We previously generated in vitro models of BoHV-4 persistent infection in human rhadomyosarcoma and bovine macrophage cell lines by drug selection of cells infected with BoHV-4 carrying a drug-resistance marker, and demonstrated circular episomal BoHV-4 genomes. In the present study, we used fluorescent in situ hybridization (FISH) to demonstrate BoHV-4 genomes also integrated into the genomes of these persistently infected cells.

摘要

牛疱疹病毒 4 型（BoHV-4）持续感染巨噬细胞，与细菌感染一起，被认为在奶牛产后子宫内膜炎中起次要因果作用。BoHV-4 持续感染的维持机制尚不清楚。我们之前通过携带耐药标记的 BoHV-4 感染细胞的药物选择，在人横纹肌肉瘤和牛巨噬细胞系中建立了 BoHV-4 持续感染的体外模型，并证明了环状附加体 BoHV-4 基因组。在本研究中，我们使用荧光原位杂交（FISH）证明 BoHV-4 基因组也整合到这些持续感染细胞的基因组中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be2b/2949847/b5acfea8e5d0/1743-422X-7-246-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be2b/2949847/b5acfea8e5d0/1743-422X-7-246-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be2b/2949847/b5acfea8e5d0/1743-422X-7-246-1.jpg

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本文引用的文献

1
Isolation and characterization of bovine herpesvirus 4 (BoHV-4) from a cow affected by post partum metritis and cloning of the genome as a bacterial artificial chromosome.从患产后子宫炎的奶牛中分离和鉴定牛疱疹病毒 4 型（BoHV-4），并将基因组克隆为细菌人工染色体。
Reprod Biol Endocrinol. 2009 Aug 19;7:83. doi: 10.1186/1477-7827-7-83.
2
Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle.定义牛产后子宫疾病以及生殖道感染和免疫的机制。
Biol Reprod. 2009 Dec;81(6):1025-32. doi: 10.1095/biolreprod.109.077370. Epub 2009 May 13.
3
Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD.
用牛疱疹病毒4型载体分泌嵌合肽BVDV-E2/BoHV-1-gD的双重免疫策略
Vaccine. 2008 Nov 11;26(48):6031-42. doi: 10.1016/j.vaccine.2008.09.023. Epub 2008 Sep 21.
4
Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease.子宫内膜基质细胞的细菌感染影响牛疱疹病毒4立即早期基因激活：对子宫疾病中细菌与病毒相互作用的新见解。
Reproduction. 2008 Sep;136(3):361-6. doi: 10.1530/REP-08-0171. Epub 2008 Jun 24.
5
Characterization of a balanced reciprocal translocation, rcp(9;11)(q27;q11) in cattle.牛中一种平衡相互易位rcp(9;11)(q27;q11)的特征分析
Cytogenet Genome Res. 2007;119(3-4):231-4. doi: 10.1159/000112066. Epub 2008 Feb 1.
6
Potential secondary pathogenic role for bovine herpesvirus 4.牛疱疹病毒4潜在的继发致病作用。
J Clin Microbiol. 2005 Jul;43(7):3421-6. doi: 10.1128/JCM.43.7.3421-3426.2005.
7
A bovine macrophage cell line supports bovine herpesvirus-4 persistent infection.一种牛巨噬细胞系支持牛疱疹病毒4型持续感染。
J Gen Virol. 2001 May;82(Pt 5):1181-1185. doi: 10.1099/0022-1317-82-5-1181.
8
Establishment of a cell line persistently infected with bovine herpesvirus-4 by use of a recombinant virus.利用重组病毒建立持续感染牛疱疹病毒4型的细胞系。
J Gen Virol. 2000 Jul;81(Pt 7):1807-14. doi: 10.1099/0022-1317-81-7-1807.
9
Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis.通过凝胶电泳检测哺乳动物细胞中的环状和线性疱疹病毒DNA分子。
J Virol. 1984 Apr;50(1):248-54. doi: 10.1128/JVI.50.1.248-254.1984.
10
Experimental inoculation of cattle with bovine herpesvirus-4: evidence for a lymphoid-associated persistent infection.用牛疱疹病毒4型对牛进行实验性接种：淋巴组织相关持续性感染的证据
Am J Vet Res. 1983 Jun;44(6):975-80.