Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College Street, Room 407, Toronto, Ontario, Canada M5S 3G9.
Macromol Biosci. 2010 Nov 10;10(11):1286-301. doi: 10.1002/mabi.201000202.
Functional vascularization is a key requirement for the development and function of most tissues, and most critically cardiac muscle. Rapid and irreversible loss of cardiomyocytes during cardiac infarction directly results from the lack of blood supply. Contractile cardiac grafts, engineered using cardiovascular cells in conjunction with biomaterial scaffolds, are an actively studied method for cardiac repair. In this article, we focus on biomaterial scaffolds designed to mediate the development and maturation of vascular networks, by immobilized growth factors. The interactive effects of multiple vasculogenic factors are discussed in the context of cardiac tissue engineering.
功能性血管化是大多数组织(尤其是心肌)发育和功能的关键要求。在心肌梗死过程中,心肌细胞的快速且不可逆转的丧失直接归因于血液供应的缺乏。利用心血管细胞与生物材料支架构建的收缩型心脏移植物是一种用于心脏修复的研究热点方法。在本文中,我们重点关注设计用于通过固定生长因子来调节血管网络发育和成熟的生物材料支架。在心脏组织工程的背景下,讨论了多种血管生成因子的相互作用。