Ito Yoshihiro
Nano Medical Engineering Laboratory, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako-shi, Saitama 351-0198, JAPAN.
Soft Matter. 2007 Dec 11;4(1):46-56. doi: 10.1039/b708359a.
Immobilization of biosignal molecules including growth factors and cytokines is important for developing biologically active materials which can contribute to tissue engineering as a component. The immobilization has more meanings than only immobilization of the enzyme in a bioreactor or ligand-receptor interactions, because the immobilized biosignal molecules work on cells which have very complex structures and functions. This review discusses recent progress in immobilization of biosignal molecules, including the mechanisms and design concepts.
固定包括生长因子和细胞因子在内的生物信号分子对于开发作为组织工程组件的生物活性材料至关重要。这种固定化的意义不仅仅在于在生物反应器中固定酶或配体-受体相互作用，因为固定化的生物信号分子作用于具有非常复杂结构和功能的细胞。本文综述了生物信号分子固定化的最新进展，包括其机制和设计理念。
