Mellors R C, Mellors J W
Arthritis Rheum. 1978 Jun;21(5 Suppl):S68-75. doi: 10.1002/art.1780210910.
An antigen recognized by antisera produced against p30 (core) proteins of the four chief groups of mammalian type C viruses (murine, feline, RD-114 related to endogenous primate, and infectious primate group) is located in an immune-complex pattern in some renal glomeruli of human SLE patients with lupus proliferative glomerulonephritis but is not detected in normal or pathological control human kidneys. This antigen cross-reacts with p30 interspecies determinants shared by the four chief virus groups and cross-reacts with a partially purified antigen extracted from human SLE spleen. The human SLE spleen antigen cross-reacts with p30 group antigen of RD-114 virus but not of feline or murine viruses. Some host immunoglobulins eluted from a human SLE kidney by acid-buffer show antibody-like activity against p30 group antigen of RD-114 virus but not of simian, feline, or murine viruses.
一种抗原可被针对哺乳动物C型病毒四个主要组（鼠类、猫类、与内源性灵长类相关的RD - 114以及传染性灵长类组）的p30（核心）蛋白产生的抗血清识别。该抗原以免疫复合物的形式存在于患有狼疮增殖性肾小球肾炎的人类系统性红斑狼疮（SLE）患者的一些肾小球中，但在正常或病理对照的人类肾脏中未被检测到。这种抗原与四个主要病毒组共有的p30种间决定簇发生交叉反应，并且与从人类SLE脾脏中提取的部分纯化抗原有交叉反应。人类SLE脾脏抗原与RD - 114病毒的p30组抗原发生交叉反应，但与猫类或鼠类病毒的p30组抗原不发生交叉反应。一些通过酸缓冲液从人类SLE肾脏中洗脱的宿主免疫球蛋白表现出针对RD - 114病毒p30组抗原的抗体样活性，但对猿猴、猫类或鼠类病毒的p30组抗原无此活性。
