Ricart Arbona Rodolfo J, Lipman Neil S, Wolf Felix R
Tri-Institutional Training Program in Laboratory Animal Medicine and Science, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College and The Rockefeller University, New York, New York, USA.
J Am Assoc Lab Anim Sci. 2010 Sep;49(5):633-7.
We determined the efficacy of ivermectin-compounded feed against fur mites in mice and describe its use to eradicate mites in vivaria holding approximately 30,000 cages. C57BL/6NCrl mice infested with Myobia musculi and Myocoptes musculinus were treated with ivermectin-compounded feed (approximate ingested dose, 1.3 mg/kg) for 1, 4, or 8 consecutive weeks. Regardless of treatment duration, all treated mice, as well as contact sentinels, remained free of fur mites for as long as 21 wk after treatment. No adverse effects were observed. Subsequently, facility-wide treatment was implemented in an attempt to eradicate fur mites from 3 vivaria housing approximately 120,000 mice. Medicated feed was provided for 8 wk to ensure that all cages and mice were treated. A single investigative group reported adverse effects in their colony 4 wk after treatment was initiated; mortality was attributed to ivermectin toxicity after an intracranial injection at 1 d of age. Naïve pups were unaffected. No other adverse effects were noted. Approximately 14,500 skin scrape samples were evaluated during the 12-mo posttreatment surveillance period. All samples were negative for mites. To our knowledge, this is the first report of successful eradication of fur mites from a mouse colony of this large size.
我们确定了伊维菌素复合饲料对小鼠皮螨的疗效，并描述了其在约30,000个饲养笼的实验动物饲养室中根除螨虫的应用。用伊维菌素复合饲料（摄入剂量约为1.3 mg/kg）对感染了肌内鼠螨和鼠肌螨的C57BL/6NCrl小鼠连续治疗1、4或8周。无论治疗持续时间如何，所有接受治疗的小鼠以及接触哨兵在治疗后的长达21周内均未感染皮螨。未观察到不良反应。随后，在三个饲养约120,000只小鼠的实验动物饲养室中实施了全设施范围的治疗，以试图根除皮螨。提供含药饲料8周，以确保所有饲养笼和小鼠都得到治疗。一个研究小组报告说，在开始治疗4周后，其群体出现了不良反应；1日龄小鼠经颅内注射后死亡归因于伊维菌素毒性。新生幼崽未受影响。未观察到其他不良反应。在治疗后的12个月监测期内，评估了约14,500份皮肤刮片样本。所有样本的螨虫检测均为阴性。据我们所知，这是首次成功从如此大规模的小鼠群体中根除皮螨的报告。
