从冲绳海洋海绵高氏海绵（Hyrtios altum）中提取的阿尔托海汀B和C以及5-去乙酰基阿尔托海汀A，它们是阿尔托海汀A的强效细胞毒性大环内酯类同系物。
Altohyrtins B and C and 5-desacetylaltohyrtin A, potent cytotoxic macrolide congeners of altohyrtin A, from the Okinawan marine sponge Hyrtios altum.
作者信息
Kobayashi M, Aoki S, Sakai H, Kihara N, Sasaki T, Kitagawa I
机构信息
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1993 May;41(5):989-91. doi: 10.1248/cpb.41.989.
Following the characterization of altohyrtin A (1), altohyrtins B (2) and C (3) and 5-desacetylaltohyrtin A (4) have been isolated from the Okinawan marine sponge Hyrtios altum and their plane structures and parts of their relative configurations elucidated. Three congeneric macrolides (2, 3, and 4) exhibit extremely potent cytotoxicities similar to those of 1 against KB cells with IC50 values of 0.02, 0.4, and 0.3 ng/ml, respectively.
在对高海鞘素A（1）进行表征之后，高海鞘素B（2）、C（3）和5-去乙酰高海鞘素A（4）已从冲绳海洋海绵高海鞘中分离出来，并且它们的平面结构及其相对构型的部分已得到阐明。三种同属大环内酯类化合物（2、3和4）表现出与1类似的极强细胞毒性，对KB细胞的IC50值分别为0.02、0.4和0.3 ng/ml。
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