Kobayashi M, Aoki S, Sakai H, Kihara N, Sasaki T, Kitagawa I
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Chem Pharm Bull (Tokyo). 1993 May;41(5):989-91. doi: 10.1248/cpb.41.989.
Following the characterization of altohyrtin A (1), altohyrtins B (2) and C (3) and 5-desacetylaltohyrtin A (4) have been isolated from the Okinawan marine sponge Hyrtios altum and their plane structures and parts of their relative configurations elucidated. Three congeneric macrolides (2, 3, and 4) exhibit extremely potent cytotoxicities similar to those of 1 against KB cells with IC50 values of 0.02, 0.4, and 0.3 ng/ml, respectively.
在对高海鞘素A（1）进行表征之后，高海鞘素B（2）、C（3）和5-去乙酰高海鞘素A（4）已从冲绳海洋海绵高海鞘中分离出来，并且它们的平面结构及其相对构型的部分已得到阐明。三种同属大环内酯类化合物（2、3和4）表现出与1类似的极强细胞毒性，对KB细胞的IC50值分别为0.02、0.4和0.3 ng/ml。
