Kojima S, Kaminaka K, Kiyozumi M, Honda T
Toxicol Appl Pharmacol. 1986 May;83(3):516-24. doi: 10.1016/0041-008x(86)90234-6.
Sodium N-benzyl-D-glucamine dithiocarbamate (NBG-DTC), which was newly synthesized, 2,3-dimercaptopropanol (BAL), and N-methyl-D-glucamine dithiocarbamate (NMG-DTC) were compared for their relative efficacies in the distribution and excretion of cadmium in rats exposed to cadmium. Rats were injected ip with 109CdCl2 (1 mg Cd and 10 microCi 109Cd/kg) and 3 days later, they were treated with the chelating agents (400 mumol/kg) every other day for 2 weeks. These chelating agents were effective in removing cadmium from the body without increasing the amount of cadmium in the kidney. After treatment with these chelating agents, cadmium was excreted mainly in the feces through the bile and the fecal excretion of cadmium by NBG-DTC was significantly larger than that by BAL or NMG-DTC. The hepatic cadmium content after treatment with NBG-DTC was much more decreased than that with BAL or NMG-DTC. The renal cadmium content was decreased only after treatment with NBG-DTC. These chelating agents did not result in the redistribution of cadmium to brain, testes, and heart. The growth of rats was little retarded by treatment with NBG-DTC and NMG-DTC, but was retarded by treatment with BAL. The treatment with NBG-DTC decreased the tissue amounts of Zn, Fe, and Mn to a small extent as compared with the treatment with cadmium alone. The results of this study reveal that the injection of NBG-DTC to rats pretreated with cadmium can more effectively remove cadmium from the body without the mobilization of cadmium to the kidney, the critical organ in cadmium toxicity, and without redistribution of cadmium to other tissues such as brain, testes, and heart, than injection of BAL and NMG-DTC.
对新合成的N-苄基-D-葡糖胺二硫代甲酸盐（NBG-DTC）、2,3-二巯基丙醇（BAL）和N-甲基-D-葡糖胺二硫代甲酸盐（NMG-DTC）在镉暴露大鼠体内镉的分布和排泄方面的相对疗效进行了比较。给大鼠腹腔注射109CdCl2（1毫克镉和10微居里109Cd/千克），3天后，每隔一天用螯合剂（400微摩尔/千克）处理2周。这些螯合剂能有效从体内清除镉，而不会增加肾脏中的镉含量。用这些螯合剂处理后，镉主要通过胆汁经粪便排出，NBG-DTC使镉的粪便排泄量显著大于BAL或NMG-DTC。用NBG-DTC处理后肝脏中的镉含量比用BAL或NMG-DTC处理后降低得更多。仅在用NBG-DTC处理后肾脏中的镉含量才降低。这些螯合剂不会导致镉重新分布到脑、睾丸和心脏。用NBG-DTC和NMG-DTC处理对大鼠生长的抑制作用较小，而用BAL处理则会抑制大鼠生长。与仅用镉处理相比，用NBG-DTC处理使锌、铁和锰的组织含量有小幅度降低。本研究结果表明，给预先用镉处理的大鼠注射NBG-DTC比注射BAL和NMG-DTC能更有效地从体内清除镉，且不会使镉转移到镉毒性的关键器官肾脏，也不会使镉重新分布到脑、睾丸和心脏等其他组织。
