From the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; the Department of Community Health, Brown University, Providence, Rhode Island; the Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Obstet Gynecol. 2010 Oct;116(4):858-864. doi: 10.1097/AOG.0b013e3181f3a1f9.
To estimate the association between maternal pregnancy-related hypertension and offspring hypertension later in life in a birth cohort from New England.
Covariate and exposure data were collected between 1959 and 1966 through the Collaborative Perinatal Project. Follow-up information was obtained through the New England Family Study between 2001 and 2004, when study participants were between 34 and 44 years old. The study population consisted of 1,556 individuals. Participants who reported having hypertension diagnosed at least once were considered to have hypertension. Logistic regression was used to estimate the association between maternal pregnancy-related hypertension and offspring hypertension later in life. Results were adjusted for sex, maternal race, maternal body mass index, maternal socioeconomic status, maternal diabetes, and twin pregnancy.
Maternal pregnancy-related hypertension was associated with an increased risk of being prescribed antihypertensives compared with never having hypertension diagnosed (from 8.8% to 17.4%; adjusted odds ratio 1.88, 95% confidence interval 1.00-3.55). The association was not attenuated after adjustment for birth weight or preterm delivery. After excluding offspring of women who reported hypertension during pregnancy only, this association increased to an adjusted odds ratio of 1.97 (95% confidence interval 1.04-3.72).
In a birth cohort from New England, maternal pregnancy-related hypertension was associated with hypertension in offspring later in life.
II.
在新英格兰的一个出生队列中，估计与母体妊娠相关的高血压与后代生命后期高血压之间的关联。
协变量和暴露数据于 1959 年至 1966 年期间通过合作围产期项目收集。通过新英格兰家庭研究在 2001 年至 2004 年期间获得随访信息，当时研究参与者年龄在 34 至 44 岁之间。研究人群由 1556 人组成。报告至少一次被诊断为高血压的参与者被认为患有高血压。使用逻辑回归来估计母体妊娠相关高血压与后代生命后期高血压之间的关联。结果根据性别、母亲种族、母亲体重指数、母亲社会经济地位、母亲糖尿病和双胞胎妊娠进行调整。
与从未被诊断出高血压的人相比，母体妊娠相关高血压与被开处降压药的风险增加相关（从 8.8%升至 17.4%；调整后的优势比 1.88，95%置信区间 1.00-3.55）。调整出生体重或早产后，这种关联并未减弱。排除仅报告妊娠期间高血压的女性的后代后，这种关联增加到调整后的优势比为 1.97（95%置信区间 1.04-3.72）。
在新英格兰的一个出生队列中，母体妊娠相关高血压与后代生命后期的高血压有关。
II。
