Zinner S
Department of Medicine, Brown University, Roger Williams General Hospital, Providence, R.I.
Chemotherapy. 1990;36 Suppl 1:50-2. doi: 10.1159/000238818.
The Italian multihospital study of bacteriuria in pregnancy randomized 153 pregnant bacteriuric patients to receive fosfomycin trometamol (FT) as a single dose of 3 g and 138 such patients to receive conventional therapy with pipemidic acid (PA), 400 mg b.i.d. for seven days. The two groups were well matched for age, parity, pregnancy course, symptoms and past history of cystitis. Infecting organisms were eradicated in 147 (96%) of FT and 129 (94%) of PA patients. Similar recurrence rates occurred. Minimal side effects (mostly nausea and dyspepsia) occurred (9%) FT; 15% PA). Single-dose FT appeared equivalent to conventional treatment with PA.
意大利多家医院开展的关于孕期菌尿症的研究，将153例孕期菌尿症患者随机分为两组，一组接受3克单剂量的磷霉素氨丁三醇（FT）治疗，另一组138例患者接受常规疗法，服用吡哌酸（PA），每日两次，每次400毫克，疗程七天。两组在年龄、产次、孕期过程、症状及膀胱炎既往史方面匹配良好。FT组147例（96%）和PA组129例（94%）的感染病原体得以根除。复发率相似。副作用轻微（主要为恶心和消化不良），FT组发生率为9%，PA组为15%。单剂量FT似乎与PA常规治疗效果相当。
