Department of Physics, 8 Clarkson Ave, Clarkson University, Potsdam, NY 13699-5820, USA.
Small. 2010 Oct 18;6(20):2314-9. doi: 10.1002/smll.201001337.
The first successful approach to synthesizing ultrabright fluorescent mesoporous silica nanoparticles is reported. Fluorescent dye is physically entrapped inside nanochannels of a silica matrix created during templated sol-gel self-assembly. The problem of dye leakage from open channels is solved by incorporation of hydrophobic groups in the silica matrix. This makes the approach compatible with virtually any dye that can withstand the synthesis. The method is demonstrated using the dye Rhodamine 6G. The obtained 40-nm silica particles are about 30 times brighter than 30-nm coated water-soluble quantum dots. The particles are substantially more photostable than the encapsulated organic dye itself.
首次成功合成超亮荧光介孔硅纳米粒子的方法被报道。荧光染料通过模板辅助溶胶-凝胶自组装过程中在二氧化硅基质的纳米通道中物理包埋。通过在二氧化硅基质中引入疏水性基团解决了染料从开放通道中泄漏的问题。这使得该方法几乎与任何能够承受合成过程的染料兼容。该方法使用染料罗丹明 6G 进行了演示。所得到的 40nm 二氧化硅颗粒比 30nm 包覆的水溶性量子点亮约 30 倍。与封装的有机染料本身相比，这些颗粒具有更高的光稳定性。
