地尔硫䓬与地高辛联合治疗对血清地高辛浓度的影响
[Effect of combined treatment of diltiazem and digoxin on serum digoxin concentration].
作者信息
Zhang J L, Wu H S, Li Q L
机构信息
Department of Medicine, Jishuitan Hospital, Beijing.
出版信息
Zhonghua Nei Ke Za Zhi. 1990 Nov;29(11):646-8, 701.
PMID:2086003
Abstract
Diltiazem is one of the effective calcium channel blocking agents. Up to now it has not been reported in our country that whether the combined use of digoxin and diltiazem can increase the serum concentration of digoxin The results of a study of ten cases with chronic congestive heart failure showed that diltiazem can increase the serum concentration of digoxin from 38.7% to 49.6%. Four of the ten cases appeared to have signs of digitalis poisoning in the electrocardiogram.
摘要
地尔硫䓬是一种有效的钙通道阻滞剂。目前在我国尚未见有关地高辛与地尔硫䓬合用是否会提高地高辛血清浓度的报道。一项对10例慢性充血性心力衰竭患者的研究结果显示，地尔硫䓬可使地高辛血清浓度提高38.7%至49.6%。10例患者中有4例在心电图上出现洋地黄中毒迹象。
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