Department of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou, China.
Oral Dis. 2011 Apr;17(3):270-6. doi: 10.1111/j.1601-0825.2010.01736.x. Epub 2010 Sep 23.
Coronary heart disease (CHD) and chronic periodontitis (CP) both are multifactorial chronic diseases and related to inflammation. Interleukin-6 (IL-6) plays an important role in the pathogenesis of inflammatory diseases. The purpose of the study was to investigate the association among IL-6 gene polymorphisms, CP and CHD susceptibility in a Chinese population.
The investigation was conducted as a case-control study involving 505 individuals: 113 patients with CHD and CP, 84 patients with CHD, 178 patients with CP and 130 control individuals. The polymorphisms of IL-6 gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Relationships between the distributions of the genotypes and risk factors were also assessed.
Mutations at the loci -174 G/C, -597 G/A of IL-6 were rare in a Chinese population. No significant difference for IL-6-572C/G polymorphism was detected among moderate CP group, severe CP group and control (P = 0.312 and 0.481), significant differences were found between CHD groups and non-CHD groups (P ≤ 0.001). After adjustment for CHD risk factors, the G allele resulted in an increased risk (OR = 1.676-1.856), the GG/CG genotype was nearly two times higher risk compared to CC genotype (OR = 2.010-2.136).
IL-6-572C/G polymorphism did not correlate with CP susceptibility, but might be a potential risk factor for CHD in a Chinese population.
冠心病（CHD）和慢性牙周炎（CP）都是多因素的慢性疾病，与炎症有关。白细胞介素-6（IL-6）在炎症性疾病的发病机制中起着重要作用。本研究旨在探讨白细胞介素-6基因多态性与中国人群 CP 和 CHD 易感性的关系。
该研究采用病例对照研究设计，共纳入 505 名个体：113 名 CHD 合并 CP 患者、84 名 CHD 患者、178 名 CP 患者和 130 名对照个体。采用聚合酶链反应-限制性片段长度多态性分析 IL-6 基因多态性。还评估了基因型和危险因素分布之间的关系。
在中国人群中，IL-6 基因座-174 G/C、-597 G/A 突变罕见。CP 中度组、重度组和对照组之间，IL-6-572C/G 多态性无显著差异（P = 0.312 和 0.481），CHD 组与非 CHD 组之间存在显著差异（P ≤ 0.001）。校正 CHD 危险因素后，G 等位基因增加了患病风险（OR = 1.676-1.856），GG/CG 基因型与 CC 基因型相比，患病风险几乎增加了两倍（OR = 2.010-2.136）。
IL-6-572C/G 多态性与 CP 易感性无关，但可能是中国人群 CHD 的潜在危险因素。
