与肿瘤坏死因子-α（G308A）、白细胞介素-6（C174G）相关的基因多态性与冠状动脉粥样硬化性心脏病易感性的荟萃分析

Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease: A meta-analysis.

作者信息

Yuepeng Jiang, Zhao Xiaoxuan, Zhao Yang, Li Liu

机构信息

Department of Heilongjiang University of Chinese Medicine.

Department of Hebei College of Chinese Medicine, Shijiazhuang.

出版信息

Medicine (Baltimore). 2019 Jan;98(2):e13813. doi: 10.1097/MD.0000000000013813.

To evaluate the association between gene polymorphisms of TNF-α G308A, IL-6 C174G, and coronary atherosclerotic heart disease (CHD) risk.We used computers to collect related case-control studies. After screening, a meta-analysis was conducted to assess the strength of association by Stata 12.0 software.Thirty-five articles were included. Among them, 17 studies were related to TNF-α (G308A) gene mutation and CHD, and 18 studies examined IL-6 (C174G) gene mutation. According to the results of subgroup analysis of ethnicity, it suggested that TNF-α (G308A) polymorphism was not significantly associated with CHD risk under all models in Asians (P > .05). There were no connected of IL-6 C174G polymorphism with CHD risk under all models in Caucasians after subgroup analysis (P > .05).The present evidence shows that TNF-α (G308A) have no connected with the risk of CHD in Asians; IL-6 (C174G) gene were not associated with the risk of CHD in Caucasians.

为评估肿瘤坏死因子-α（TNF-α）G308A、白细胞介素-6（IL-6）C174G基因多态性与冠状动脉粥样硬化性心脏病（CHD）风险之间的关联。我们使用计算机收集相关病例对照研究。筛选后，采用Stata 12.0软件进行荟萃分析以评估关联强度。共纳入35篇文章。其中，17项研究涉及TNF-α（G308A）基因突变与CHD，18项研究检测了IL-6（C174G）基因突变。根据种族亚组分析结果，提示在亚洲人中，TNF-α（G308A）多态性在所有模型下与CHD风险均无显著关联（P>0.05）。亚组分析后，在白种人中，IL-6 C174G多态性在所有模型下与CHD风险均无关联（P>0.05）。现有证据表明，TNF-α（G308A）与亚洲人CHD风险无关；IL-6（C174G）基因与白种人CHD风险无关。